PAN-DR binding polypeptides and uses thereof
AssigneeEpimmune Inc.
InventorsFlorence Dal Degan, Mark J. Newman, Jeffery L. Alexander, Scott Southwood
Life of this patent
Estimating the term…
Abstract
The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein X1 is H; X2 is selected from the group consisting of F, N, Y and W; X3 is H and X4 is selected from the group consisting of A, D and E. The invention also relates to large peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.
Claims12
An isolated oligopeptide that can bind to at least three different HLA-DR alleles with an IC50 value of less than 100 nM, wherein the oligopeptide sequence comprises AX1FVAAX2TLX3AX4A (SEQ ID NO:
- 1), wherein
- X1 is H;
- X2 is selected from the group consisting of F, N, Y and W;
- and
- X3 is H;
- and
- X4 is selected from the group consisting of A, D and E.
An isolated polypeptide comprising an oligopeptide sequence that can bind to at least three different HLA-DR alleles with an IC50 value of less than 100 nM, wherein the oligopeptide sequence comprises AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein
- X1 is H;
- X2 is selected from the group consisting of F, N, Y, and W;
- and
- X3 is H;
- and
- X4 is selected from the group consisting of A, D and E.
Dependencies are inferred from the claim text.