D-amino acid derivative-modified peptidoglycan and methods of use thereof
AssigneeThe Regents of the University of California
InventorsCarolyn R. Bertozzi, Mary Sloan Siegrist Palmore, John C. Jewett, Chelsea G. Gordon, Peyton Shieh
Life of this patent
Estimating the term…
Abstract
The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.
Claims19
A modified bacterial cell comprising a modified peptidoglycan, wherein the modified peptidoglycan comprises at least one modified D-amino acid, wherein the at least one modified D-amino acid is an azide-modified, an alkyne-modified, or a norbornene-modified D-amino acid.
A modified bacterial cell comprising a modified peptidoglycan, wherein the modified peptidoglycan comprises at least one modified D-amino acid conjugated to a reagent via a heterocycle, wherein the at least one modified D-amino acid is an azide-modified, an alkyne-modified, or a norbornene-modified D-amino acid, and the reagent is an azide-containing reagent, an alkynyl reagent or a norbornene-reactive reagent.
Dependencies are inferred from the claim text.