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US 9,789,176 B2Granted
Compositions and methods for inducing immune responses against bacteria in the genus staphylococcus
AssigneeRegents of the University of Minnesota
InventorsPatrick M. Schlievert, Marnie L. Peterson
Life of this patent
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Abstract
This disclosure features compositions that include two or more staphylococcal toxoids and are useful for inducing protective immune responses against staphylococcal diseases.
Claims18
A composition comprising two or more staphylococcal toxoids, said composition comprising:
- (a) at least one toxoid selected from the group consisting of a staphylococcal enterotoxin-like X (SEL-X) toxoid, an alpha toxin toxoid, a beta toxin toxoid, and a gamma toxin toxoid;
- and
- (b) at least one toxoid selected from the group consisting of a toxic shock syndrome toxin-1 (TSST-1) toxoid, a staphylococcal enterotoxin B (SEB) toxoid comprising SEQ ID NO:3 but having one or more of the following:
- a threonine at position 20, an alanine residue at position 90, a valine residue at position 91, or an alanine residue at position 210, and a staphylococcal enterotoxin C (SEC) toxoid.
1 more element
A composition comprising a) a TSST-1 toxoid, a SEC toxoid, a staphylococcal alpha toxin toxoid, a staphylococcal beta toxin toxoid, and a gamma toxin toxoid, or b) a TSST-1 toxoid, a SEC toxoid, and a staphylococcal alpha toxin toxoid.
Dependencies are inferred from the claim text.