Synthetic immunogens for prophylaxis or treatment of tuberculosis

A composition comprising one or more optimized nucleic acid molecule selected from the group consisting of:

• a) one or more nucleic acid molecule selected from the group consisting of:
• an optimized nucleic acid molecule comprising esxV, esxS and esxW coding sequences, an optimized nucleic acid molecule comprising esxD, esxQ and esxE coding sequences, an optimized nucleic acid molecule comprising esxH, esxA and esxT coding sequences, an optimized nucleic acid molecule comprising esxB, esxC and esxU coding sequences, and an optimized nucleic acid molecule comprising esxO, esxR and esxF coding sequences;
• b) one or more nucleic acid molecule selected from the group consisting of:
• a nucleic acid molecule comprising SEQ ID NO:19 or SEQ ID NO:1, a nucleic acid molecule comprising SEQ ID NO:21 or SEQ ID NO:3, a nucleic acid molecule comprising SEQ ID NO:23 or SEQ ID NO:5, a nucleic acid molecule comprising SEQ ID NO:25 or SEQ ID NO:7, and a nucleic acid molecule comprising SEQ ID NO:27 or SEQ ID NO:9;
• c) one or more nucleic acid molecule selected from the group consisting of:
• a nucleic acid molecule comprising SEQ ID NO:19, a nucleic acid molecule comprising SEQ ID NO:21, a nucleic acid molecule comprising SEQ ID NO:23, a nucleic acid molecule comprising SEQ ID NO:25, and a nucleic acid molecule comprising SEQ ID NO:27;
• d) one or more nucleic acid molecule selected from the group consisting of:
• a nucleic acid molecule that encodes SEQ ID NO:20, a nucleic acid molecule that encodes SEQ ID NO:22, a nucleic acid molecule that encodes SEQ ID NO:24, a nucleic acid molecule that encodes SEQ ID NO:26, and a nucleic acid molecule that encodes SEQ ID NO:28;
• e) one or more nucleic acid molecule selected from the group consisting of:
• a nucleic acid molecule that comprises SEQ ID NO:1, a nucleic acid molecule that comprises SEQ ID NO:3, a nucleic acid molecule that comprises SEQ ID NO:5, a nucleic acid molecule that comprises SEQ ID NO:7, a nucleic acid molecule that comprises SEQ ID NO:9, a nucleic acid molecule that comprises SEQ ID NO:19, a nucleic acid molecule that comprises SEQ ID NO:21, a nucleic acid molecule that comprises SEQ NO:23, a nucleic acid molecule that comprises SEQ NO:25, a nucleic acid molecule that comprises SEQ ID NO:27, fragments thereof having at least 90% of full length, homologous sequences having at least 95% homology, and fragments of homologous sequences having at least 95% homology, said fragment of homologous sequences having at least 95% homology having at least 90% of full length;
• and
• f) one or more nucleic acid molecule that encodes an amino acid sequence selected from the group consisting of:
• SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:8, SEQ ID NO:
• 10, SEQ ID NO:20, SEQ ID NO:22, SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, fragments thereof having at least 90% of full length, homologous sequences having at least 95% homology, and fragments of homologous sequences having at least 95% homology, said fragments of homologous sequences having at least 95% homology having at least 90% of full length.