Methods and compositions for modulating the immune system with arginase I
AssigneeBio-Cancer Treatment International Limited
InventorsGernot Schabbauer, Stephen Bluml, Emine Sahin-Heco, Paul Cheng, Li Chen
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Abstract
Methods and compositions comprising recombinant Arginase I proteins which are capable of depleting the plasma arginine levels in a subject are disclosed. The methods and compositions can be used to modulate the activity of the immune system in a subject. Modulation of the immune system is useful in the treatment of immune disorders and in preventing rejection of a transplanted organ, tissue, or cell. The methods and compositions can also be used to treat a bone condition of a subject.
Claims39
A method of treating multiple sclerosis in a subject in need thereof, the method comprising administering to the subject suffering from multiple sclerosis a therapeutically-effective amount of a purified pegylated Arginase I or a functional fragment thereof, wherein the purified pegylated Arginase I or functional fragment thereof treats the multiple sclerosis by inhibiting T-cell polarization.
A method of treating inflammation associated with a T-cell mediated autoimmune disease, the method comprising:
- administering to a subject suffering from the inflammation associated with the T-cell mediated autoimmune disease a therapeutically-effective amount of a purified pegylated Arginase I, or a functional fragment thereof, wherein the administration of the purified pegylated Arginase I, or the functional fragment thereof, treats the inflammation by inhibiting T-cell polarization.
Dependencies are inferred from the claim text.