Polypeptide mixes with antibacterial activity
AssigneeMicreos Human Health B.V.
InventorsMartin Johannes Loessner, Fritz Eichenseher
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Abstract
The invention relates to the field of microbiology, specifically to a combination of a source of a first enzymatic active domain and a source of a second enzymatic active domain and to a composition comprising said combination. The invention further relates to a composition comprising said combination for use as a medicament, to the use of said composition as an antimicrobial agent and to a method for controlling microbial contamination in a food- or feed product, on and/or in food- or feed processing equipment, on and/or in food- or feed containers.
Claims7
A composition comprising a combination of a source of a first enzymatic active domain and a source of a second enzymatic active domain, wherein said source comprises a polypeptide, wherein said first and second enzymatic active domains each exhibit distinct target bond specificities and are comprised on a distinct first and second polypeptide, and wherein said first and second polypeptide comprise a different number of copies of said first and/or second enzymatic active domain, and wherein said first polypeptide comprises a sequence that has at least 80% sequence identity to SEQ ID NO:
- 58, said second polypeptide comprises a sequence that has at least 80% sequence identity to SEQ ID NO:
- 70.
A composition comprising a combination of a source of a first enzymatic active domain, a source of a second enzymatic active domain, and a source of a third enzymatic domain,
- wherein said source comprises a polypeptide;
- wherein each of said first, second and third enzymatic active domains exhibits distinct target bond specificities and are comprised of distinct first, second and third polypeptides and each of said distinct first, second and third polypeptides comprises a different number of copies of said first, second and third enzymatic active domains, and further comprises a cell wall-binding domain;
- wherein said first enzymatic active domain is a cysteine, histidine-dependent amidohydrolases/peptidase domain, said second enzymatic active domain is an endopeptidase domain, said third enzymatic domain is an amidase domain;
- and
- wherein said first polypeptide comprises a sequence that has at least 80% sequence identity to SEQ ID NO:
- 58, said second polypeptide comprises a sequence that has at least 80% sequence identity SEQ ID NO:
- 70 and said third polypeptide comprises a sequence that has at least 80% sequence identity SEQ ID NO:
- 52.
Dependencies are inferred from the claim text.