Assessment of cardiac health and thrombotic risk in a patient

A method of treating a vascular disease in a patient, the method comprising:

• administering a platelet inhibitor therapy to the patient;
• assaying in vitro platelet function in a blood sample from the patient, wherein platelet function is assayed by assaying platelet reactivity, time-to-thrombin formation (TTF), or time-to-fibrin formation (TFF) in a blood sample in response to an agonist, wherein assaying platelet reactivity is by a method other than assaying GP IIb/IIIa receptor expression, said assaying in vitro platelet function providing a test score, wherein the test score is independent of a pre-treatment baseline of platelet reactivity in the patient;
• identifying the patient as at risk of a thrombotic event when the test score for the patient is greater than a risk threshold score based on a population study;
• and
• administering an adjusted platelet inhibitor therapy to reduce platelet reactivity, or to increase at least one of TTF and TFF, in the patient identified as at risk of a thrombotic event.