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US 9,789,165 B2Granted
Exendin-4 peptide analogues as dual GLP-1/GIP receptor agonists
AssigneeSanofi
InventorsDieter Kadereit, Katrin Lorenz, Andreas Evers, Torsten Haack, Michael Wagner, Bernd Henkel, Martin Lorenz, Siegfried Stengelin
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Abstract
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
Claims23
A peptidic compound of formula (I):
- R1—Z—R2 (I)
- or a salt or solvate thereof,
- wherein Z is a peptide moiety of formula (II):
- Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Ile-Gln-X14-X15-Lys-Arg-Ala-Ala-Aib-Glu- Phe-Ile-Glu-Trp-Leu-Lys-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-X40 (II)
- wherein:
- X14 is an amino acid residue selected from Met, Leu, and Nle,
- X15 is an amino acid residue selected from Glu and Asp,
- X40 is absent or is Lys,
- R1 is NH2, and
- R2 is OH or NH2.
7 more elements
Dependencies are inferred from the claim text.