Compositions for prevention of adhesions and other barrier applications
AssigneeArch Biosurgery, Inc.
InventorsRutledge Ellis-Behnke, Terrence W. Norchi, Stephen Richard Kelly
Life of this patent
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Abstract
A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material which forms a barrier to formation of adhesions. In certain embodiments, the self assembling materials are peptidomimetics, nucleotidomimetics, di- and triblock copolymers, N-alkylacrylamides, or dendimers. These materials are also useful in a method for regeneration or repair of tissue or cells forming tissue.
Claims19
A method of preventing or limiting formation of scar tissue at a wound or surgery site or a site of inflammation comprising
- topically administering to diseased or damaged skin or epithelial tissue a formulation comprising self-assembling peptides which form a barrier to contamination and loss of fluid from the diseased or damaged skin or epithelial tissue,
- wherein the formulation does not include cells, and
- wherein the barrier is effective to reduce or prevent the formation of scar tissue at the site of administration relative to an untreated control.
Dependencies are inferred from the claim text.