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US 9,789,138 B1Granted
Neural repair construct and method of use
AssigneeBioDlogics, LLC
InventorsTimothy B. Brahm, Greg Brophy
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Abstract
A neural repair construct fabricated from human birth tissue comprising at least one cross-linked amniotic membrane, or at least one cross-linked chorionic membrane, or at least one amniotic membrane, or at least one chorionic membrane, or any combination thereof wherein the membrane(s) is/are treated with at least one alcohol composition followed by terminal sterilization is provided. Methods of processing a membrane to form a neural repair construct, methods of repairing a nerve and associated kits are also provided.
Claims11
A method of repairing a severed nerve, comprising the steps of:
- providing a neural repair construct comprising:
- at least one cross-linked amniotic membrane, or
- at least one cross-linked chorionic membrane, or
- at least one amniotic membrane, or
- at least one chorionic membrane, or
- any combination thereof;
- securing a first nerve stump of the severed nerve to a first end of the construct;
- and
- securing a second nerve stump of the severed nerve to a second, opposing end of the construct,
- wherein the membrane(s) is/are chemically dehydrated with a single ethanol composition for about 24 hours to about 384 hours, the ethanol composition comprising from about 90% to about 100% ethanol, and
- wherein the membrane(s) is/are terminally sterilized after chemical dehydration to form a neural repair construct.
8 more elements
Dependencies are inferred from the claim text.