Enhanced reconstitution and autoreconstitution of the hematopoietic compartment
AssigneeTaiga Biotechnologies, Inc.
InventorsBrian C. Turner, Yosef Refaeli, Gregory Alan Bird
Life of this patent
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Abstract
The present disclosure relates to the acceleration of hematopoietic compartment reconstitution in a subject in need of hematopoietic stem cell transplantation by administering a composition having a protein transduction domain-MYC (PTD-MYC) fusion protein in combination with hematopoietic stem cell transplantation and to the enhancement of hematopoietic compartment autoreconstitution in a subject in need thereof by administering a composition having a protein transduction domain-MYC (PTD-MYC) fusion protein.
Claims14
A method of enhancing hematopoietic compartment reconstitution in a subject in need of hematopoietic stem cell transplantation, the method comprising:
- administering to the subject, a therapeutically effective amount of a treated population of hematopoietic stem cells to reconstitute the hematopoietic compartment of the subject, wherein the treated population of hematopoietic stem cells is a population of hematopoietic stem cells that are treated with a composition comprising a MYC-composition, a Bcl-2-composition, or both, for less than or about 1 day prior to administering to the subject, wherein the MYC composition and the Bcl-2 composition each comprise a protein transduction domain (PTD), and
- wherein hematopoietic compartment reconstitution is enhanced compared to hematopoietic compartment reconstitution in a subject that is administered a population of hematopoietic stem cells that were not treated with the composition comprising a MYC-composition, a Bcl-2-composition, or both.
A method of enhancing hematopoietic compartment reconstitution in a subject, the method comprising:
- administering a therapeutically effective amount of a composition comprising a MYC-composition, a Bcl-2-composition, or both, to a subject in need thereof, wherein the MYC composition and the Bcl-2 composition each comprises a protein transduction domain (PTD), and wherein hematopoietic compartment reconstitution is enhanced compared to hematopoietic compartment reconstitution in a subject that is not administered the composition.
Dependencies are inferred from the claim text.