Methods and materials for treating calcific aortic valve stenosis
AssigneeMayo Foundation for Medical Education and Research
InventorsJordan D. Miller, Bin Zhang
Life of this patent
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Abstract
This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.
Claims4
A method for slowing progression of calcification of a heart valve, wherein said method comprises:
- (a) identifying a mammal having heart valve calcification, and
- (b) administering a sGC agonist to said mammal, wherein said sGC agonist is the sole active ingredient administered in the amount ranging from 50 mg/day to 200 mg/day to said mammal, wherein said sGC agonist slows progression of calcification of a heart valve within said mammal, and wherein the sGC agonist is 5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide.
A method for slowing progression of aortic valve sclerosis to calcific aortic valve stenosis, wherein said method comprises:
- (a) identifying a mammal having aortic valve sclerosis, and
- (b) administering a sGC agonist to said mammal, wherein said sGC agonist is the sole active ingredient administered in the amount ranging from 50 mg/day to 200 mg/day to said mammal, wherein said sGC agonist slows progression of aortic valve sclerosis to calcific aortic valve stenosis within said mammal, and wherein the sGC agonist is 5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide.
Dependencies are inferred from the claim text.