Cognitive function
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsCraig C. Garner, H Craig Heller, Damien Colas, Daniel Z. Wetmore
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Abstract
Provided herein are methods, drug formulations, and dosing regimens for improving cognitive function in a normal or cognitively impaired subject. For instance, methods provided herein comprise administering a GABAA receptor antagonist so that peak concentration of the GABAA receptor antagonist occurs when the subject is asleep.
Claims11
A method for improving a cognitive function in a human subject with Down syndrome comprising administering to the human subject a therapeutically effective dose of a GABAA receptor chloride ionophore blocker, wherein the GABAA receptor chloride ionophore blocker is pentylenetetrazole, picrotoxin or bilobalide, in a circadian cycle sensitive manner so that peak concentration of the GABAA receptor chloride ionophore blocker in the human subject occurs when the human subject is asleep, wherein the administering is effective to achieve improvement in the Down syndrome.
Dependencies are inferred from the claim text.