Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof

A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is represented by formula (IV):

• wherein:
• one of X5 or X6 is N and the other is CH;
• and
• p is 0, 1, 2, or 3
• Q is selected from the group consisting of:
• wherein the symbol
• indicates the point of attachment to ring B;
• X4 is —NR4— or —O—;
• q and n are each, independently, 0, 1, 2, 3, or 4;
• L1 is —NHSO2—, —SO2NH—, —NHSO2NH— or —NHC(O)NH—;
• R1 may replace a hydrogen atom of any CH bond in ring A and, for each occurrence, is independently deutero, hydroxy, nitro, halo, cyano, carboxy, formyl, C1-7alkyl, C3-8 carbocyclyl, C2-7alkenyl, C2-7alkynyl, C1-7alkoxy, C1-7alkylthio, C3-8cycloalkoxy, C6-10aryl, C6-10arylC1-4alkyl, C6-10aryloxy, amino, N—C1-7alkylamino, N,N-di-(C1-7alkyl)amino, N—C6-10arylamino, 3- to 10-membered heterocyclyl, N-(3- to 10-membered heterocyclyl)amino, (3- to 10-membered heterocyclyl)oxy, 5- to 10-membered heteroaryl, (5- to 10-membered heteroaryl)C1-4alkyl, N-(5- to 10-membered heteroaryl)amino, (5- to 10-membered heteroaryl)oxy, C1-7alkanoyl, C1-7alkoxycarbonyl, C1-7alkanoyloxy, C1-7alkylamido, C6-10arylamido, (3- to 10-membered heterocyclyl)amido, carbamoyl, N—C1-7alkylcarbamoyl, N,N-di-(C1-7alkyl)carbamoyl, C1-7alkoxyamido, C1-7alkylureido, and C6-10arylureido, wherein R1 is optionally substituted on one or more carbon atom with one or more independently selected R13;
• and wherein when R1 comprises a heterocyclyl or a heteroaryl comprising one or more —NH—, the hydrogen of each —NH— group may be independently optionally replaced with R22;
• or two R1 on the same carbon atom together may form an oxo;
• or two R1 on the same carbon atom together with the carbon to which they are attached form a spiro C3-8carbocyclyl;
• or two R1 on adjacent carbon atoms together with the carbon atoms to which they are attached may form a fused C3-8carbocyclyl or phenyl which may be optionally substituted with one or more R13;
• and
• R3 is selected from the group consisting of a C1-7alkyl, C3-8carbocyclyl, C3-8carbocyclylC1-4alkyl, C6-10aryl, C6-10arylC1-4alkyl, a 5- to 10-membered heteroaryl, a (5- to 10-membered heteroaryl)C1-4alkyl, a 3- to 10-membered heterocyclyl, and a (3- to 10-membered heterocyclyl)C1-4alkyl, wherein R3 is optionally substituted on one or more carbon atom with one or more R14;
• and wherein when R3 comprises a heteroaryl or heterocyclyl comprising one or more —NH—, the hydrogen of each —NH— group may be independently optionally replaced with a C1-7alkyl;
• R4 is hydrogen, C1-7 alkyl, or C1-4alkoxyC1-4alkyl;
• or R3 and R4, together with the nitrogen atom to which they are attached form a 3- to 7-membered heterocyclyl, wherein the heterocyclyl may be optionally substituted on one or more carbon atoms with one or more R15;
• and wherein when the heterocyclyl comprises one or more —NH—, the hydrogen of each —NH— group may be independently optionally replaced with R16;
• R13, for each occurrence, is independently deutero, nitro, halo, cyano, hydroxy, carboxy, C1-7alkyl, C3-8cycloalkyl, C1-7alkoxy, C6-10aryl, C6-10aryloxy, 3- to 10-membered heterocyclyl, 5- to 10-membered heteroaryl, amino, C1-7alkylamino, di-(C1-7alkyl)amino, C1-7alkanoyl, C1-7alkoxycarbonyl, C1-7alkanoyloxy, C1-7alkylamido, C1-7alkoxyamido, carbamoyl, N—C1-7alkylcarbamoyl, N,N-di-(C1-7alkyl)carbamoyl, C1-7alkylsufonyl, C1-7alkylsulfonyloxy, C1-7alkylsulfonamido, sulfamoyl, N—C1-7alkylsulfamoyl, or N,N-di-(C1-7alkyl)sulfamoyl, wherein R13 is optionally substituted on one or more carbon atom with one or more independently selected R17;
• and wherein when R13 is a heterocyclyl or a heteroaryl comprising one or more —NH—, the hydrogen of each —NH— group may be independently optionally replaced with R20;
• or two R13 on the same carbon atom together may form an oxo or a spiro C3-8carbocyclyl;
• or two R13 on adjacent carbon atoms together with the carbons to which they are attached may form a 3- to 7-membered heterocyclyl which may be optionally substituted on one or more carbon atom with one or more R17 and if the heterocyclyl comprises one or more —NH— group, the hydrogen of each —NH— group may be independently optionally replaced with R20;
• R14, for each occurrence, is independently halo, hydroxy, carboxy, C1-7alkoxycarbonyl, C1-7alkyl, C1-7alkoxy, C3-8cycloalkyl, C6-10aryl, or 5- to 10-membered heteroaryl, wherein R14 may be optionally substituted on one or more carbon atoms with one or more independently selected R24;
• or two R14 on the same carbon atom together may form an oxo, a spiro C3-8carbocyclyl or a 3- to 7-membered spiro heterocyclyl;
• or two R14 on adjacent carbon atoms together with the carbon atoms to which they are attached may form a phenyl which may be optionally substituted on one or more carbon atoms with one or more R24;
• R15, for each occurrence, is independently selected from the group consisting of hydroxy, carboxy, C1-7alkyl, C1-7alkoxy, C3-8carbocyclyl, phenyl, and C1-7alkoxycarbonyl;
• wherein R15 may be optionally substituted on one or more carbon atoms with one or more substituent independently selected from halo, hydroxy, C1-4alkoxy;
• or two R15 on the same carbon atom together form an oxo or together with the carbon atom to which they are attached form a C2-8cycloalkyl or a 3- to 10-membered heterocyclyl;
• or two R15 on adjacent carbon atoms together with the carbon atoms to which they are attached may form a fused phenyl;
• R16, for each occurrence, is independently selected from the group consisting of C1-7alkyl, C3-8carbocyclyl, C1-7alkanoyl, C1-7alkoxycarbonyl, or 5- to 10-membered heteroaryl;
• R17, for each occurrence, is independently selected from cyano, halo, hydroxy, carboxy, C1-7alkyl, C1-7alkoxy, amino, C1-7alkylamino, di-(C1-7alkyl)amino, C6-10arylamino, C6-10arylC1-4alkylamino, C1-7alkoxycarbonyl, C1-7alkanoyloxy, 3- to 10-membered heterocyclyl, wherein R17 may be optionally substituted on one or more carbon atoms with one or more independently selected halo, amino, C1-7alkyl, C1-7alkoxy, C1-7haloalkyl, carboxy, or C1-7alkyoxycarbonyl;
• and wherein when R17 is a heterocyclyl comprising one or more —NH—, the hydrogen of each —NH— group may be independently optionally replaced with R23;
• or two R17 on the same carbon atom together may form an oxo;
• R18 is a C1-7alkyl, C3-8cycloalkyl, phenyl or a C1-7alkoxyC1-7alkyl;
• R20, R22, and R23, for each occurrence, are independently deutero, halo, carboxy, C1-7alkyl, C1-7alkoxy, C6-10aryloxy, C6-10arylC1-4alkoxy, or C1-7alkoxycarbonyl;
• and
• R24, for each occurrence, is independently hydroxy, halo, carboxy, C1-7alkyl, C1-7haloalkyl, C1-7alkoxy, amino, N—C1-7alkylamino, N,N-di-(C1-7alkyl)amino, C1-7alkoxycarbonyl, C1-7alkanoyloxy, phosphonooxy, C1-7alkoxy(hydroxy)phosphoryloxy or di-(C1-7alkoxy)phosphoryloxy;
• wherein R24 may be optionally substituted on one or more carbon atom with a group independently selected from amino, N—C1-7alkylamino, and phenyl.