Back to results
US 9,789,106 B2Granted
Foamable otic pharmaceutical compositions
AssigneeOtic Pharma Ltd.
InventorsEvgenia Lozinsky, Yanna Galibov, Rodrigo Yelin
Life of this patent
Estimating the term…
Abstract
The present invention relates a foamable otic pharmaceutical compositions comprising oil-in water emulsions which comprise an antibiotic agent and a propellant gas. The pharmaceutical compositions are administered to the ear as foam for treating ear disorders.
Claims17
A foamable otic pharmaceutical composition comprising:
- (a) an oil-in-water emulsion comprising:
- (i) an antibiotic agent in an amount effective for antibacterial action;
- (ii) an analgesic or anesthetic agent;
- (iii) water in an amount of at least 75% (w/w) of the total weight of the emulsion;
- (iv) mineral oil in an amount of no more than 15% (w/w) of the total weight of the emulsion;
- (v) a synthetic surfactant pharmaceutically acceptable for otic use;
- (vi) a foaming agent selected from a fatty alcohol and a fatty acid;
- (vii) white petrolatum in an amount that does not exceed 3% (w/w) of the total weight of the emulsion;
- and
- (b) a compressed propellant gas;
- wherein the oil-in-water emulsion is devoid of organic polar co-solvents, the organic polar co-solvents being polyols,
- wherein the oil-in-water emulsion has an osmolarity of about 280 mOsm/L to about 320 mOsm/L, and
- wherein the composition, packaged in a container, is adapted to form a foam after dispensing from the container.
10 more elements
Dependencies are inferred from the claim text.