Inhibitors of calcium-activated chloride channels
AssigneeThe Regents of the University of California
InventorsAlan S. Verkman, Ricardo De La Fuente Gonzalez
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Abstract
Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.
Claims17
A composition comprising a physiologically acceptable excipient and a compound having the following structure (I):
- or a pharmaceutically acceptable salt, prodrug or stereoisomer thereof,
- wherein
- R1 is hydrogen or optionally substituted alkyl;
- R2 is hydroxy, optionally substituted alkoxy, or optionally substituted phenylamino;
- R3 is alkyl substituted with —COOH, alkenyl substituted with —COOH, optionally substituted cycloalkyl, optionally substituted phenyl, or optionally substituted heterocyclyl;
- and
- n is 0, 1, or 2, and
- wherein the compound of structure I comprises at least one —COOH, and provided that when n is 1, R1 is branched alkyl.
Dependencies are inferred from the claim text.