Methods of inhibiting cataracts and presbyopia
AssigneeUniversity of Massachusetts
InventorsMurugappan Muthukumar, Benjamin Mohr
Life of this patent
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Abstract
Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a γ-crystallin charge masking agent. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins.
Claims24
A method of inhibiting or reversing the progression of cataract formation, presbyopia, or age related degeneration of a crystalline lens in an eye comprising
- contacting the eye, including the crystalline lens, of a subject in need thereof with an effective cataract-inhibiting amount of an ophthalmic composition comprising at least one γ-crystallin charge masking agent,
- wherein the γ-crystallin charge masking agent is a bifunctional molecule containing
- NH2, a succinimide, a carboxylic acid, isocyanate, isothiocyanate, sulfonyl chloride, aldehyde, carbodiimide, acyl azide, anhydride, fluorobenzene, carbonate, N-hydroxysuccinimide ester, imidoester, epoxide or a fluorophenyl ester,
- covalently linked to a molecular bristle that is a polyethylene glycol, an alkoxy-polyethylene glycol, or an alkoxypolyethylene glycol having 4 to 200 oxyethylene, alkoxyethylene or aryloxyethylene groups;
- poly(2-hydroxypropyl)methacrylamide (HPMA);
- poly(2-hydroxyethyl)methacrylate (HEMA);
- a ply(2-oxaziline), poly(m-phosphocholine), poly lysine, or poly glutamic acid, the molecular bristle having a molecular weight of 150 to 8000.
A method of inhibiting or reversing the progression of cataract formation, presbyopia, or age related degeneration of a crystalline lens in an eye comprising
- contacting the eye of a subject in need thereof with an effective cataract-inhibiting amount of an ophthalmic composition comprising at least one γ-crystallin charge masking agent,
- wherein the γ-crystallin charge masking agent is a bifunctional molecule containing
- NH2, N-hydroxysuccinimide or COOH
- covalently linked to
- a molecular bristle that is a polyethylene glycol, an alkoxy-polyethylene glycol, or an alkoxypolyethylene glycol having 4 to 200 oxyethylene, alkoxyethylene or aryloxyethylene groups;
- poly(2-hydroxypropyl)methacrylamide (HPMA);
- poly(2-hydroxyethyl)methacrylate (HEMA);
- a ply(2-oxaziline), poly(m-phosphocholine), poly lysine, or poly glutamic acid, the molecular bristle having a molecular weight of 150 to 8000.
Dependencies are inferred from the claim text.