PAR4 inhibitor therapy for patients with PAR4 polymorphism
AssigneeThomas Jefferson University
InventorsPaul Bray, Michael Holinstat, Leonard Edelstein
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Abstract
Disclosed herein are methods for determining whether a PAR4 inhibitor should be administered to a human subject, the methods comprising administering a PAR4 inhibitor to a subject determined to have a “G” allele for a single-nucleotide polymorphism (SNP) at rs773902, and not administering a PAR4 inhibitor to a subject determined to have an “A” allele for the SNP at rs773902. A genotyping assay can be used to determine the SNP.
Claims7
A method of preventing or treating thrombosis in a human subject in need thereof, the method comprising administering a therapeutically effective amount of a PAR4 inhibitor to a human subject determined to have a “G” allele for a single-nucleotide polymorphism (SNP) at rs773902.
Dependencies are inferred from the claim text.