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US 9,789,086 B1Granted
N-(5-arylamido-2-methylphenyl)-5-methylisooxazole-4-carboxamide deravative, pharmaceutical acceptable salt thereof, method for preparation therof and FMS kinase inhibitor comprising the same as anactive ingredient
AssigneeIndustry-University Cooperation Foundation Hanyang University Erica Campus
InventorsJung-Mi Hah, Kyung Jin Jung
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Abstract
The present invention relates to N-(5-arylamido-2-methylphenyl)-5-methylisoquoxazole-4-carboxamide derivative, or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising same. The compound according to the present invention exhibits an FMS kinase inhibitory activity and thus can be used as pharmaceutical composition for preventing and treating diseases associated therewith.
Claims10
A compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 is hydrogen and R2 is R3, or R1 is R3 and R2 is hydrogen,
- R3 is —NHCO—R4, —NHCONH—R5, or —NHSO2—R6,
- R4 is (1H-indol-3-yl)methyl;
- 1-acetylpiperidin-4-yl;
- 1-phenyl-5-(trifluoromethyl)-1H-pyrazolyl;
- 6-hydroxy-2,5,7,8-tetramethylchroman-2-yl;
- benzotriazolyl;
- biphenyl;
- di(4-chlorophenyl)methyl;
- indolinyl;
- pyrazinyl;
- pyridinyl;
- quinolinyl;
- phenyl substituted with one or two substituents each independently selected from the group consisting of C1-4 alkyl, C1-4 haloalkyl, halogen, morpholino, imidazolyl substituted with methyl, piperazinyl substituted with methyl, and cyanophenylthio;
- or benzyl substituted with halogen or phenyl,
- R5 is phenyl substituted with one or two substituents each independently selected from the group consisting of C1-4 haloalkyl and halogen, and
- R6 is C1-4 alkyl.
15 more elements
Dependencies are inferred from the claim text.