Back to results
US 9,789,082 B2Granted
Somatostatin receptor subtype 4 (SSTR4) agonists
AssigneeCentrexion Therapeutics Corporation
InventorsRiccardo Giovannini, Yunhai Cui, Henri Doods, Marco Ferrara, Stefan Just, Raimund Kuelzer, Iain Lingard, Rocco Mazzaferro, Klaus Rudolf
Life of this patent
Estimating the term…
Abstract
3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.
Claims38
A method for the treatment of pain which comprises administering to a host suffering from pain a therapeutically effective amount of a compound of Formula I to treat the pain, wherein Formula I is represented by:
- or a salt thereof, wherein:
- A is selected from the group consisting of H and C1-6-alkyl;
- R1 and R2 are independently selected from the group consisting of H, C1-6-alkyl and C3-6-cycloalkyl, wherein at least one of R1 or R2 is C1-6-alkyl or C3-6-cycloalkyl, and the C1-6-alkyl or the C3-6-cycloalkyl is optionally substituted with halogens or MeO—;
- W is a mono- or bicyclic heteroaryl, each of which is optionally substituted with one or more R3, and wherein the heteroaryl comprises up to 4 heteroatoms and one or two 5- or 6-membered ring(s);
- R3 is independently selected from the group consisting of C1-6-alkyl, C1-6-alkyl-O—, halogen, HO—, and NC—;
- and
- Y is selected from the group consisting of a bond, —CH2—, —CH2CH2—, and —CH2O—.
4 more elements
Dependencies are inferred from the claim text.