Ophthalmic formulations of mycophenolic acid
AssigneesInsite Vision Incorporated, Gholam Peyman
InventorsSui Yuen Eddie Hou, Lyle M. Bowman, Tang Nguyen, Gholam Peyman
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Abstract
Ophthalmic formulations including mycophenolic acid or salt thereof in an aqueous medium having a reduced level of dissolved oxygen and processes for making such formulations and using such formulations are disclosed.
Claims14
An ophthalmic formulation comprising mycophenolic acid or salt thereof as an active ingredient in an aqueous medium with a reduced level of dissolved oxygen relative to saturation level, wherein the oxygen level is less than 3 ppm, and wherein at least 90% of an initial amount of the mycophenolic acid or salt thereof as an active ingredient remains in the ophthalmic formulation after a period of at least 18 months from an initial preparation of the ophthalmic formulation.
An ophthalmic formulation comprising mycophenolic acid or salt thereof as an active ingredient and an alkali thiosulfate in an aqueous medium with a reduced level of dissolved oxygen relative to saturation level;
- wherein the oxygen level is less than 3 ppm.
Dependencies are inferred from the claim text.