Easily dosable solid preparation
AssigneeMochida Pharmaceutical Co., Ltd.
InventorsYumio Kudou, Kuniomi Warabino, Hiromitsu Ito
Life of this patent
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Abstract
It has been desired to develop a coating composition, which is used for an orally-administered preparation having an improved administering property, and/or an easily administrable preparation that does not affect dissolution property. The present invention provides a coating composition comprising: a first thickener selected from the group consisting of a carboxyvinyl polymer and sodium alginate; a polyvalent metal compound; at least one type of a second thickener selected from the group consisting of xanthan gum, guar gum and sodium alginate, with the proviso that when the first thickener is sodium alginate the second thickener is not sodium alginate; and sucralose.
Claims14
A coating composition comprising:
- a first thickener selected from the group consisting of a carboxyvinyl polymer and sodium alginate;
- a polyvalent metal compound;
- at least one type of a second thickener selected from the group consisting of xanthan gum, guar gum and sodium alginate, with the proviso that when the first thickener is sodium alginate the second thickener is not sodium alginate;
- hydroxypropylmethylcellulose;
- and
- a sugar or sugar alcohol having a solubility at 20° C. of 30 g or more in 100 ml of water,
- wherein the content of the first thickener is 3% to 20% by mass, and the content of the hydroxypropylmethylcellulose is 5% to 35% by mass, wherein % by mass is based on total mass of all ingredients excluding a solvent, and
- wherein the coating composition is configured for coating at least one drug core selected from the group consisting of a tablet core, a pill core, a capsule core, a pellet core and a granule core.
An oral composition having:
- a drug core containing an active ingredient;
- and
- over the drug core,
- a coating comprising
- a first thickener selected from the group consisting of a carboxyvinyl polymer and sodium alginate,
- a polyvalent metal compound,
- at least one type of a second thickener selected from the group consisting of xanthan gum, guar gum and sodium alginate, with the proviso that when the first thickener is sodium alginate the second thickener is not sodium alginate,
- hydroxypropylmethylcellulose;
- and
- a sugar or sugar alcohol having a solubility at 20° C. of 30 g or more in 100 ml of water,
- wherein the content of the first thickener is 3% to 20% by mass, and the content of the hydroxypropylmethylcellulose is 5% to 35% by mass, wherein % by mass is based on total mass of all ingredients in the coating, and
- wherein the drug core is at least one drug core selected from the group consisting of a tablet core, a pill core, a capsule core, a pellet core and a granule core.
Dependencies are inferred from the claim text.