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US 9,789,065 B2Granted
Process for producing oral dosage forms with controlled release
AssigneeBASF SE
InventorsKarl Kolter, Angelika Maschke
Life of this patent
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Abstract
A process for producing solid oral dosage forms with controlled active ingredient release, comprising a mixture of a) at least one active ingredient, and b) a preformulated mixture of polyvinyl acetate and polyvinylpyrrolidone, wherein the mixture is obtained by joint processing of components a) and b) in an extruder at temperatures between 50° and 200° C.
Claims1
A process for producing solid oral dosage forms with controlled active ingredient release, comprising a mixture of:
- a) at least one active ingredient, and
- b) a preformulated mixture of polyvinyl acetate and polyvinylpyrrolidone;
- wherein the mixture is obtained by joint processing of components a) and b) in an extruder at temperatures between 80° and 180° C.;
- wherein said preformulated mixture is obtained by dissolving polyvinylpyrrolidone in a fine-particle aqueous dispersion of polyvinyl acetate with a particle size of the polyvinyl acetate particles of from 100 to 300 nm, and subsequently spray driving;
- and wherein extrusion takes place under a pressure of from 2 to 25 MPa;
- wherein a film with a layer thickness of 100-1000 μm is extruded, from which small pieces of film for oral administration are cut out directly thereafter.
3 more elements
Dependencies are inferred from the claim text.