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US 9,789,059 B2Granted
Oral disintegrating tablet
AssigneeBoehringer Ingelheim International GmbH
InventorsManabu Nakatani, Yohei Kawabata, Takeshi Sawada, Hiroshi Takasaki
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Abstract
A process for the preparation of an oral disintegrating tablet comprising the antihypertensive telmisartan and the tablet obtained by the process.
Claims12
A process for the preparation of a telmisartan tablet comprising
- 1) (a) spraying an aqueous solution of telmisartan, a basic agent and a surfactant on to a first filler and a flow control agent to obtain a first granulate and drying the granulate;
- 2) (b) coating the first granulate with a coating agent selected from the group consisting of corn starch, pregelatinized starch, lactose, D-mannitol, erythritol and microcrystalline cellulose to obtain a coated granulate;
- 3) (c) drying and screening the coated granulate;
- 4) (d) blending the dried and screened coated granulate with a second filler selected from the group consisting of cellulose, dibasic calcium phosphate anhydrous, erythritol, mannitol, microcrystalline cellulose corn starch, and pregelatinized starch, a flow control agent and a disintegrant selected from the group consisting of sodium starch glycolate, crospovidone, corn starch and pregelatinized starch;
- and
- 5) (e) tableting the blend using external lubrication in the presence of a lubricant.
3 more elements
Dependencies are inferred from the claim text.