Back to results
US 9,788,767 B1Granted
System and method for monitoring nitric oxide levels using a non-invasive, multi-band biosensor
AssigneeSanmina Corporation
InventorRobert Steven Newberry
Life of this patent
Estimating the term…
Abstract
A biosensor includes a PPG circuit that emits light directed at living tissue at a plurality of wavelengths. A first and second spectral response of light reflected from the tissue is obtained around a first wavelength and a second wavelength. Using absorption coefficients for substances at the plurality of wavelengths, concentration levels of a plurality of substances such as Nitric Oxide may then be determined from the spectral responses.
Claims14
A biosensor for monitoring nitric oxide (NO) of a patient in vivo, comprising:
- a PPG circuit configured to:
- generate at least a first spectral response for light reflected around a first wavelength from skin tissue of the patient;
- generate at least a second spectral response for light reflected around a second wavelength from the skin tissue of the patient;
- a processing circuit configured to:
- obtain a value Lλ1 using the first spectral response, wherein the value Lλ1 isolates the first spectral response due to pulsating arterial blood flow;
- obtain a value Lλ2 using the second spectral response, wherein the value Lλ2 isolates the second spectral response due to pulsating arterial blood flow;
- obtain a value Rλ1, λ2 from a ratio of the value Lλ1 and the value Lλ2;
- and
- obtain a concentration level of nitric oxide using the value Rλ1, λ2 and a calibration database, wherein the calibration database is used to correlate the value Rλ1, λ2 and the concentration level of nitric oxide (NO).
6 more elements
A method for monitoring nitric oxide (NO) of a patient in vivo, comprising:
- obtaining at least a first spectral response for light reflected around a first wavelength from skin tissue of the patient;
- obtaining at least a second spectral response for light reflected around a second wavelength from the skin tissue of the patient;
- obtaining a value Lλ1 using the first spectral response, wherein the value Lλ1 isolates the first spectral response due to pulsating arterial blood flow;
- obtaining a value Lλ2 using the second spectral response, wherein the value Lλ2 isolates the second spectral response due to pulsating arterial blood flow;
- obtaining a value Rλ1, λ2 from a ratio of the value Lλ1 and the value Lλ2;
- and
- obtaining a concentration level of nitric oxide using the value Rλ1, λ2 and a calibration database, wherein the calibration database correlates the value Rλ1, λ2 and the concentration level of nitric oxide (NO).
4 more elements
Dependencies are inferred from the claim text.