Seizure prediction

A system comprising:

• an impedance sensing module configured to measure an impedance of a brain of a patient, and generate impedance measurements indicative of the impedance of the brain, wherein the impedance of the brain is indicative of a physiological state of the brain;
• a processor coupled to the impedance sensing module, wherein the processor is configured to receive impedance measurements from the impedance sensing module, determine a trend in the impedance measurements over time, and determine that the brain is in a state indicative of a possibility of a future seizure based on the trend;
• and
• a therapy delivery module coupled to the processor, wherein the processor is configured to control delivery of therapy to the patient via the therapy delivery module in response to determining that the brain is in the state indicative of the possibility of the future seizure.

A system comprising:

• means for measuring an impedance of a brain of a patient, wherein the impedance of the brain is indicative of a physiological state of the brain;
• means for generating impedance measurements of the brain of the patient based on the measured impedance;
• means for determining a trend in the impedance measurements over time;
• means for determining that the brain is in a state indicative of a possibility of a future seizure based on the trend;
• and
• means for delivering therapy to the patient in response to the means for determining that the brain is in the state indicative of the possibility of the future seizure.

A non-transitory computer-readable medium comprising instructions that cause a programmable processor to:

• receive impedance measurements indicative of an impedance of a brain of a patient, wherein the impedance of the brain is indicative of a physiological state of the brain;
• determine a trend in the impedance measurements over time;
• determine that the brain is in a state indicative of a possibility of a future seizure based on the trend;
• and
• control a therapy delivery module to deliver therapy to the patient based on determining that the brain is in the state indicative of the possibility of the future seizure.

A method comprising:

• generating, with an impedance sensing module, impedance measurements indicative of an impedance of a brain of a patient, wherein the impedance of the brain is indicative of a physiological state of the brain;
• detecting, with a seizure detection module, an occurrence of a seizure;
• associating, with a processor, the occurrence of the seizure with a plurality of the impedance measurements indicative of the impedance of the brain during a period of time beginning before the occurrence of the seizure;
• determining, with the processor, a trend in the plurality of impedance measurements over time;
• subsequent to determining the trend in the plurality of impedance measurements over time, receiving, with the processor, additional impedance measurements indicative of an impedance of the brain of the patient
• determining, with the processor, the trend in the additional impedance measurements over time;
• determining, with the processor, that the brain is in a state indicative of a possibility of a future seizure based on determining the trend in the additional impedance measurements;
• and
• controlling, with the processor, delivery of therapy to the patient based on determining that the brain is in the state indicative of the possibility of the future seizure.

A system comprising:

• an impedance sensing module configured to generate impedance measurements indicative of an impedance of a brain of a patient, wherein the impedance of the brain is indicative of a physiological state of the brain;
• a seizure detection module configured to detect an occurrence of a seizure;
• a processor coupled to the impedance sensing module and the seizure detection module, wherein the processor is configured to associate the occurrence of the seizure with a plurality of the impedance measurements indicative of the impedance of the brain during a period of time beginning before the occurrence of the seizure, determine a trend in the plurality of impedance measurements over time, receive additional impedance measurements indicative of an impedance of the brain of the patient subsequent to determining the trend in the plurality of impedance measurements over time, determine the trend in the additional impedance measurements over time, and determine that the brain is in a state indicative of a possibility of a future seizure based on determining the trend in the additional impedance measurements;
• and
• a therapy delivery module coupled to the processor, wherein the processor is configured to control delivery of therapy to the patient via the therapy delivery module in response to determining that the brain is in the state indicative of the possibility of the future seizure.