Platelet protection solution having beta-galactosidase and sialidase inhibitors

A method of storing platelets, wherein isolated platelets are obtained from one or more donors, the method comprises:

• a. contacting the isolated platelets with a Platelet Protection Solution (PPS) that comprises:
• i. an amount of one or more β-galactosidase inhibitors and an amount of one or more sialidase inhibitors, and optionally an amount of one or more glycan-modifying agents, or a combination thereof;
• and
• ii. PPS components, in a form of salt, consisting essentially of:
• a sodium source in an amount ranging between about 100 mM and about 300 mM;
• a chloride source in an amount ranging between about 40 mM and about 110 mM;
• an acetate source in an amount ranging between about 10 mM and about 50 mM;
• a phosphate source in an amount ranging between about 5 mM and about 50 mM;
• a potassium source in an amount ranging between about 0.5 mM and about 10 mM;
• and
• a magnesium source in an amount ranging between about 0.5 mM and about 5.0 mM, to thereby obtain a platelet composition.