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US 9,783,567 B2Granted
Processes and intermediates for preparing anti-HIV agents
AssigneeGilead Sciences, Inc.
InventorsRichard Hung Chiu Yu, Brandon Heath Brown, Richard P. Polniaszek, Benjamin R. Graetz, Keiko Sujino, Duong Tran, Alan Scott Triman, Kenneth M. Kent, Steven Pfeiffer
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Abstract
The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
Claims5
A method of preparing a compound of formula 14:
- comprising:
- (a) converting a compound of formula 12a:
- to a compound of formula 13, wherein each R4 is independently (C1-C6)alkyl, (C3-C7)cycloalkyl, or (C3-C7)aryl, and wherein any (C3-C7)cycloalkyl or (C3-C7)aryl is unsubstituted or substituted with up to five (C1-C6)alkyl groups,
- wherein the compound of formula 12a is treated with a deprotecting agent to give a compound of formula 13;
- and (b) converting the compound of formula 13
- to the compound of formula 14, wherein the compound of formula 13 is treated with citric acid.
3 more elements
Dependencies are inferred from the claim text.