PSMA-targeting compounds and uses thereof

A compound having the following chemical structure:

• wherein Z is tetrazole or CO2Q;
• wherein each Q is independently selected from hydrogen or a protecting group, wherein the protecting group is selected from the group consisting of benzyl, p-methoxybenzyl, tertiary butyl, methoxymethyl, methoxyethoxymethyl, methylthiomethyl, tetrahydropyranyl, tetrahydrofuranyl, benzyloxymethyl, trimethylsilyl, triethylsilyl, t-butyldimethylsilyl, and triphenylmethyl;
• a is 1, 2, 3, or 4;
• R is each independently H or C1-C4 alkyl;
• Y is —C(O)—;
• V is —C(O)— or —NRC(S)—;
• m is 1, 2, 3, 4, 5, or 6;
• n is 1, 2, 3, 4, 5 or 6;
• p is 0, 1, 2, or 3, and when p is 2 or 3, each R1 may be the same or different;
• R1 is H, C1-C6 alkyl, C2-C12 aryl, or C4-C16 alkylaryl
• R2 and R3 are independently H, CO2H, or CO2R4, where R4 is a C1-C6 alkyl, C2-C12 aryl, or C4-C16 alkylaryl, wherein when one of R2 and R3 is CO2H or CO2R4, the other is H, and when p is 0, one of R2 and R3 is CO2R4, and the other is H;
• and
• Ch is a chelating moiety, optionally including a chelated metal, wherein the chelating moiety is selected from the group consisting of:
• and wherein + is the bond connecting the chelating moiety to the rest of the molecule.