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US 9,775,900 B2Granted
Photodynamic diagnosis, formulations usable as photosensitizers for this purpose, method for the production and use thereof
AssigneeSanochemia Pharmazeutika AG
InventorsStefan Welzig, Beate Kälz, József Gungl, Klaus Gerdes, Werner Frantsits, Christina Abrahamsberg
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Abstract
In the early detection of cancer, in particular bladder cancer, a photodynamic diagnosis uses, as a photosensitizer, a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone.
Claims2
A method for preparing a lyophilizate from which a photosensitizer for photodynamic diagnosis of tumors may be obtained, comprising the following successive steps:
- a) preparing a solution of a sodium or potassium salt of hypericin;
- b) dissolving a complexing agent selected from the group consisting of polyethylene glycol and poly-N-vinyl amide in the solution;
- c) adding sufficient of a buffer system comprising a phosphate buffer or a citric acid buffer to obtain a concentration of 0.0225 mg hypericin/g solution;
- and
- d) lyophilizing the solution to obtain lyophilizate to yield 0.225 mg hypericin in each resulting obtained photosensitizer.
2 more elements
Dependencies are inferred from the claim text.