# US 9,775,510 B2 · Methods to reduce variance in OCT analysis of the macula

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- Number: US 9,775,510 B2
- Document ID: US9775510B2
- Status: Granted
- Kind: B2
- Application number: 14/316,548
- Filed: 2014-06-26
- Published: 2014-10-16
- Granted: 2017-10-03
- Earliest claimed: 2010-12-23
- Assignees: Carl Zeiss Meditec AG
- Applicants: Carl Zeiss Meditec, Inc.
- Inventors: Robert W. Knighton; Matthew J. Everett; Mary K. Durbin; Jonathan D. Oakley
- Web page: https://patentgrep.com/patent/US9775510B2

## CPC

- A61B 3/102: {for optical coherence tomography [OCT]}
- A61B 3/0025: {characterised by electronic signal processing, e.g. eye models}
- G06T 7/0012: {Biomedical image inspection}
- G06T 7/12: Edge-based segmentation
- G06T 7/162: involving graph-based methods
- G06T 7/60: Analysis of geometric attributes
- G06T 2207/10101: Optical tomography; Optical coherence tomography [OCT]
- G06T 2207/30041: Eye; Retina; Ophthalmic
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL

## Abstract

Methods for analyzing optical coherence tomography (OCT) images of the macula to reduce variance and improve disease diagnosis are presented. One embodiment of the invention is directed towards selecting analysis locations and data segmentation techniques to take advantage of structural homogeneities. Another embodiment is directed towards reducing the variance in a collection of normative data by transforming the individual members of the database to correspond to a Standard Macula. Variations in foveal size are corrected by radial transformation. Variations in layer thickness are corrected by axial shifting. Diagnosis is performed by comparing OCT images from a patient to the improved normative database.

## Claims

### Claim 1

A method of assessing the degree of abnormality in a patient's eye based on measurements of the patient's eye obtained with an optical coherence tomography (OCT) device and comparing those measurements to a collection of OCT measurements of eyes of a population of normal subjects, the method comprising:
creating a standard form of the macula from a collection of measurements contained in a normative database wherein the standard form reduces the inter-individual variability within the normative data, wherein the standard form is created by aligning the collection of measurements to each other and using the mean thickness of the collection of the measurements;
spatially transforming each measurement in the collection of measurements relative to the standard form based on anatomical information;
spatially transforming the measurements of the patient's eye relative to the standard form based on anatomical information;
comparing the spatially transformed measurements of the patient's eye to the spatially transformed collection of measurements to determine the degree of abnormality in a patient's eye; and
displaying or storing the results of the comparison.

### Claim 2 (depends on 1)

A method as recited in claim 1, wherein the collection of measurements are thickness maps of the ganglion cell layer.

### Claim 3 (depends on 1)

A method as recited in claim 1, wherein the collection of measurements are thickness maps of the ganglion cell and inner plexiform layers.

### Claim 4 (depends on 1)

A method as recited in claim 1, wherein the standard form is created in polar coordinates.

### Claim 5 (depends on 1)

A method as recited in claim 1, wherein the spatial transformation involves radially shifting each measurement in the collection relative to the standard form to match the sizes of the foveal depressions.

### Claim 6 (depends on 1)

A method as recited in claim 1, wherein the spatial transformation involves radially scaling each measurement in the collection relative to the standard form to match the sizes of the foveal depressions.

### Claim 7 (depends on 1)

A method as recited in claim 1, wherein the spatial transformation involves axially shifting each measurement in the collection of measurements based on the average thickness of the measurements and the average thickness of the standard form.

### Claim 8 (depends on 1)

A method as recited in claim 1, wherein the spatial transformation involves radially shifting each measurement in the collection relative to the standard form to match the size of the foveal depressions and axially shifting each measurement in the collection of measurements based on the average thickness of the measurements and the average thickness of the standard form.

### Claim 9 (depends on 1)

A method as recited in claim 1, wherein the measurements of the patient's eye include measurements of the ganglion cell layer and the inner plexiform layer of a patient's eye.

### Claim 10 (depends on 1)

A method as recited in claim 1, wherein the standard form is created using a model representing the macula.

### Claim 11 (depends on 1)

A method as recited in claim 1, further comprising displaying the measurements as a function of position relative to the fovea.

### Claim 12 (depends on 11)

A method as recited in claim 11, wherein the measurements are displayed using polar coordinates.