# US 9,775,379 B2 · Method and system for drug delivery

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- Number: US 9,775,379 B2
- Document ID: US9775379B2
- Status: Granted
- Kind: B2
- Application number: 13/997,302
- Filed: 2011-12-22
- Published: 2013-10-24
- Granted: 2017-10-03
- Earliest claimed: 2010-12-22
- Assignees: Syqe Medical Ltd.
- Applicants: Perry Davidson; Aaron Schorr; Arie Holtz; Will Pong; Binyamin Schwartz
- Inventors: Perry Davidson; Aaron Schorr; Arie Holtz; Will Pong; Binyamin Schwartz
- Web page: https://patentgrep.com/patent/US9775379B2

## CPC

- A24F 40/42: Cartridges or containers for inhalable precursors
- A24F 40/50: Control or monitoring
- A61K 9/0004: {Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas}
- A61K 9/007: {Pulmonary tract; Aromatherapy}
- A61K 9/7007: {Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence)}
- A61M 11/041: {using heaters}
- A61M 11/042: {electrical}
- A61M 15/0003: {with means for dispensing more than one drug}
- A61M 15/0016: {located downstream of the dispenser, i.e. traversed by the product}
- A61M 15/002: {with air flow regulating means}
- A61M 15/0045: {using multiple prepacked dosages on a same carrier, e.g. blisters}
- A61M 15/0051: {the dosages being arranged on a tape, e.g. strips}
- A61M 15/0055: {the used dosages being coiled}
- A61M 15/0065: {Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52)}
- A61M 15/0066: {with means for varying the dose size}
- A61M 15/008: {Electronic counters}
- A61M 15/0081: {Locking means}
- A61M 15/0083: {Timers}
- A24F 40/20: Devices using solid inhalable precursors
- A24F 40/485: Valves; Apertures
- A61M 11/048: {with a flame, e.g. using a burner}
- A61M 2016/0021: {with a proportional output signal, e.g. from a thermistor}
- A61M 2016/0039: {in the inspiratory circuit}
- A61M 2202/062: Desiccants
- A61M 2205/12: with interchangeable cassettes forming partially or totally the fluid circuit
- A61M 2205/13: with means for the detection of operative contact with patient, e.g. lip sensor
- A61M 2205/17: with redundant control systems
- A61M 2205/18: with alarm
- A61M 2205/276: preventing unwanted use
- A61M 2205/3306: Optical measuring means
- A61M 2205/3331: Pressure; Flow
- A61M 2205/3365: Rotational speed
- A61M 2205/3368: Temperature
- A61M 2205/3553: remote, e.g. between patient's home and doctor's office
- A61M 2205/3584: using modem, internet or Bluetooth®
- A61M 2205/3592: using telemetric means, e.g. radio or optical transmission
- A61M 2205/3606: cooled
- A61M 2205/364: by chemical reaction
- A61M 2205/3653: by Joule effect, i.e. electric resistance
- A61M 2205/3673: thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors
- A61M 2205/368: by electromagnetic radiation, e.g. IR waves
- A61M 2205/502: User interfaces, e.g. screens or keyboards
- A61M 2205/52: with memories providing a history of measured variating parameters of apparatus or patient
- A61M 2205/581: by audible feedback
- A61M 2205/583: by visual feedback
- A61M 2205/587: Lighting arrangements
- A61M 2205/60: with identification means
- A61M 2205/6009: for matching patient with his treatment, e.g. to improve transfusion security
- A61M 2205/6018: providing set-up signals for the apparatus configuration
- A61M 2205/6054: Magnetic identification systems
- A61M 2205/6063: Optical identification systems
- A61M 2205/6072: Bar codes
- A61M 2205/8206: battery-operated
- A61M 2207/00: Methods of manufacture, assembly or production
- A61M 2209/06: Packaging for specific medical equipment
- A61M 2209/10: Equipment for cleaning
- G16H 20/13: delivered from dispensers
- A24F: SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES (inhaling appliances for medical purposes, shaped like cigars, cigarettes or pipes A61M15/06)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

There is provided in accordance with an exemplary embodiment of the invention, a device and a method for controlled extraction of at least one active substance from at least one type of plant matter by application of heat, the device comprising: a heating element adapted to apply heat to an area of the plant matter to extract the substance; and a mechanism adapted for moving the plant matter relative to the heating element. Optionally, the active substance is a restricted substance. There is also provided in accordance with an exemplary embodiment of the invention, a method of monitoring and controlling inhalation of a restricted substance. There is provided in accordance with an exemplary embodiment of the invention, a method of manufacturing a tape of plant matter comprising an active substance.

## Claims

### Claim 1

An inhaler device for controlled extraction of at least one active substance from at least one type of plant matter by application of heat, said inhaler device comprising:
a first layer of plant matter, said first layer having a thickness ranging from 0.2 mm to 1 mm;
a second layer in contact with said first layer for direct heating of said plant matter by said second layer, said second layer comprising apertures having a size sufficiently small to prevent said plant matter from escaping and sufficiently large to allow air to enter through said second layer;
circuitry for controlling heating of said second layer; and
a delivery tract for delivery of said active substance to a user, said delivery tract in fluid communication with an air intake tract, said air intake tract comprising at least one conduit extending from an opening of said inhaler device to said second layer, so that ambient air entering said conduit is allowed to flow from said opening to and through said second layer and to and through said first layer of plant matter;
wherein a density of plant matter in said first layer allows said air to flow from behind said first layer, through said first layer, and to said delivery tract.

### Claim 2 (depends on 1)

The device of claim 1, wherein said first layer is organized as separate individual doses, each dose including a predetermined amount of said active substance per unit area of said layer.

### Claim 3 (depends on 2)

The device according to claim 2, wherein said individual doses are separated from each other by non-vaporizable material.

### Claim 4 (depends on 2)

The device according to claim 2, wherein said individual doses are separated from each other by an inert barrier or a spacing.

### Claim 5 (depends on 1)

The device according to claim 1, further comprising a vapor chamber, said vapor chamber being in fluid communication with said delivery tract, said delivery tract ending with a mouthpiece for inhalation of said extracted substance by a user.

### Claim 6 (depends on 5)

The device of claim 5, further comprising a valve in said mouthpiece configured to allow air to enter through a secondary flow pathway, yielding a controlled flow rate of air through said second layer and plant matter.

### Claim 7 (depends on 5)

The device of claim 5, further comprising a sensor in fluid communication with said mouthpiece, said sensor adapted to estimate an air flow rate and send a signal to a controller, said controller adapted for extracting said substance according to said airflow rate.

### Claim 8 (depends on 1)

The device according to claim 1, further comprising a controller adapted to control heating of said second layer, and a memory adapted to hold at least one of prescription data and usage data, said memory coupled to said controller, said controller adapted to control heating according to said at least one of prescription data and usage data.

### Claim 9 (depends on 8)

A device according to claim 8, wherein said controller is configured to adjust at least one of a timing and a temperature of heating of said second layer to extract said active substance according to a delivery profile.

### Claim 10 (depends on 9)

The device of claim 9 wherein different delivery profiles of at least one of heating temperature applied to the first layer and timing of heating are preprogrammed in different cassettes containing said plant matter, and said delivery profiles are electronically communicated to said controller.

### Claim 11 (depends on 1)

The device according to claim 1, wherein said device comprises a pair of heating elements positioned on opposite sides of said layer of plant matter, wherein at least one of said heating elements is semipermeable.

### Claim 12 (depends on 1)

The device according to claim 1, wherein said plant matter is disposed between a pair of mesh layers.

### Claim 13 (depends on 1)

The device according to claim 1, wherein said first layer is configured such that airflow carries vapors containing said extracted substance therethrough.

### Claim 14 (depends on 1)

The device according to claim 1, wherein said second layer is configured such that heat may be directed directly toward the first layer for localized heating of said plant matter.

### Claim 15 (depends on 1)

The device according to claim 1, further comprising a second heating element, wherein said heating elements are configured to transmit heat directly to both sides of the first layer.

### Claim 16 (depends on 1)

A device according to claim 1, wherein said second layer is configured to apply heat to an area of said first layer to extract a predetermined amount of said at least one active substance.

### Claim 17 (depends on 1)

The device according to claim 1, further comprising a motor adapted for automatically moving said plant matter relative to said delivery tract.

### Claim 18 (depends on 1)

A device according to claim 1, wherein inhalation of said substance by said user is utilized to adjust heating of said second layer.

### Claim 19 (depends on 1)

The device according to claim 1, wherein said plant matter comprises particle size between 100 μm-700 μm.

### Claim 20 (depends on 1)

The device according to claim 1, wherein said plant matter comprises a macroscopic plant structure.

### Claim 21 (depends on 1)

The device according to claim 1, wherein said plant matter does not include damaged organic substances.

### Claim 22 (depends on 1)

The device according to claim 1, wherein a density of said plant matter is between 20%-50% matter.

### Claim 23 (depends on 1)

The device according to claim 1, wherein said plant matter comprises packed cannabis in organic matter form.