# US 9,775,356 B2 · Aqueous alcoholic microbicidal compositions comprising zinc ions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,775,356 B2 - Document ID: US9775356B2 - Status: Granted - Kind: B2 - Application number: 14/410,208 - Filed: 2013-06-28 - Published: 2015-08-27 - Granted: 2017-10-03 - Earliest claimed: 2012-07-02 - Assignees: Reckitt Benckiser N.V. - Applicants: Reckitt Benckiser LLC - Inventors: Mohammad Khalid Ijaz; Yun-Peng Zhu - Web page: https://patentgrep.com/patent/US9775356B2 ## CPC - A01N 59/16: Heavy metals; Compounds thereof - A01N 31/02: Acyclic compounds - A01N 33/12: Quaternary ammonium compounds - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS ## Abstract Treatment compositions which impart a microbicidal benefit to treated surfaces which compositions comprise (or in certain preferred embodiments may consist essentially of, or may consist of) as constituents: a zinc source material which releases zinc ions into the treatment composition, preferably a source of Zn++ ions; at least one lower alkyl monohydric alcohol (preferably at least about 25% wt. of a lower alkyl monohydric alcohol); at least one quaternary ammonium compound which provides a microbicidal benefit; optionally one or more further optional constituents which impart one or more advantageous technical or aesthetic benefits to the compositions, including one or more detersive surfactants; wherein the composition has a pH of at least 5, wherein the surface treatment compositions are characterized in exhibiting a microbicidal benefit, especially preferably against poliovirus type 1 Sabin (“PV1”), when tested according to one or more of the following standardized test protocols: ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension, or ASTM E1053 Standard Test Method to Assess Virucidal Activity of Chemicals Intended for Disinfection of Inanimate, Nonporous Environmental Surfaces, or European Standard Surface Test, EN13697, or AOAC Germicidal Spray Products as Disinfectant Test Method, AOAC Index, 17th Ed. (2000) against one or more challenge microorganisms. ## Claims ### Claim 1 A transparent liquid, inanimate surface treatment composition which imparts virucidal benefit to inanimate surfaces treated with said composition which composition comprises: a zinc source material which releases zinc ions into the treatment composition; about 35% wt. to 50% wt. of at least one C1-C6 alkyl aliphatic monohydric alcohol, at least one quaternary ammonium compound; water; optionally, one or more detersive surfactants; optionally, one or more further constituents which impart one or more advantageous technical or aesthetic benefits to the compositions; wherein the composition has a pH of at about 7 to about 11, wherein the surface treatment composition is characterized in exhibiting a reduction of at least 3 log 10 against poliovirus type 1 (Sabin) (“PV1”) according to ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension. ### Claim 2 (depends on 1) A composition according to claim 1 which comprises at least 40% wt. to 50% wt., of at least one C1-C6 alkyl aliphatic monohydric alcohol. ### Claim 3 (depends on 1) A composition according to claim 1 wherein ethanol is the predominant or is the sole C1-C6 alkyl aliphatic monohydric alcohol present in the composition. ### Claim 4 A liquid, inanimate surface treatment composition which imparts a virucidal benefit to surfaces treated with said composition which comprises: a zinc source material which releases zinc ions into the treatment composition; about 35% wt. to about 50% wt. of at least one C1-C6 lower alkyl aliphatic monohydric alcohol, at least one quaternary ammonium compound which provides a microbicidal benefit; water; at least one nonionic detersive surfactant; optionally, one or more further constituents which impart one or more advantageous technical or aesthetic benefits to the compositions; wherein the composition has a pH of between about 7 to 11, wherein the surface treatment composition is characterized in exhibiting a reduction of at least 3 log 10 of poliovirus type 1 (Sabin) (“PV1”) according to ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension. ### Claim 5 (depends on 4) A composition according to claim 4, which satisfies at least one of Conditions C, D, E or F: log10 reduction of poliovirus type 1 (Sabin) (“PV1”) when % wt. of at tested according to the least one standardized test protocol: lower alkyl ASTM E1052 Standard Test Con- aliphatic Method for Efficacy of di- pH or pH monohydric Antimicrobial Agents against tion range alcohol Viruses in Suspension C 9 ≦ pH < 9.5 ≧35 and ≦50 at least 3.0 D 9.5 ≦ pH < 10 ≧35 and ≦50 at least 3.33 E 10 ≦ pH < ≧40 and ≦49.9 at least 5.0 10.5 F about 7 to ≧35 and ≦49.9 at least 5.0 10.5 ≦ pH. ### Claim 6 (depends on 4) A composition according to claim 4, which concurrently satisfies at least Condition H: log10 reduction of poliovirus type 1 (Sabin) (“PV1”) when % wt. of at tested according to the least one standardized test protocol: lower alkyl ASTM E1052 Standard Test aliphatic Method for Efficacy of Condi- monohydric Antimicrobial Agents against tion alcohol pH or pH range Viruses in Suspension H ≧35 and <40 ≧9.05 and ≦9.50 at least 3.0. ### Claim 7 (depends on 1) A composition according to claim 1, which composition comprises: a zinc source material which releases zinc ions into the treatment composition; at least 40% wt. to about 50% wt. of at least one C1-C6 alkyl aliphatic monohydric alcohol, at least one quaternary ammonium compound which provides a microbicidal benefit; at least one detersive nonionic surfactant; water; optionally, one or more further constituents which impart one or more advantageous technical or aesthetic benefits to the compositions; wherein the composition has a pH of at least 8.5 but less than 11, wherein the surface treatment compositions are characterized in exhibiting at least a 3 log 10 reduction of polivirus type 1 Sabin when tested according to ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension. ### Claim 8 (depends on 1) A composition according to claim 1, in which the composition comprises: a zinc source material which releases zinc ions into the treatment composition; at least 35% wt. to about 50% wt. of at least one C1-C6 alkyl aliphatic monohydric alcohol, and wherein a) when compositions comprise 35% wt. to <45% wt. of at least one lower alkyl aliphatic monohydric alcohol, the pH of the compositions are ≧9.46 and <11; b) when compositions comprise ≧45% wt. to ≦50% wt. of at least one lower alkyl aliphatic monohydric alcohol, the pH of the compositions are ≧9.46 and <11; at least one quaternary ammonium compound which provides a microbicidal benefit; water; optionally but preferably at least one detersive surfactant; optionally, one or more further constituents which impart one or more advantageous technical or aesthetic benefits to the compositions; and, wherein the surface treatment compositions are characterized in exhibiting at least a 3 log10 result when tested against poliovirus type 1 (Sabin) (“PV1”) tested according to ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension. ### Claim 9 (depends on 1) A method of controlling the incidence of poliovirus type 1 (Sabin) (“PV1”) the method comprising the step of: contacting an inanimate surface which is in need of treatment or upon which the presence of poliovirus type 1 (Sabin) (“PV1”) are suspected or are known to be present, with an effective amount of a composition according to claim 1 to provide a microbicidal benefit to the contacted surface. ### Claim 10 (depends on 1) A composition according to claim 1 having a pH of at least about 8. ### Claim 11 (depends on 1) A composition according to claim 1 having a pH of at least about 8.5. ### Claim 12 (depends on 1) A composition according to claim 1 having a pH of at least about 9. ### Claim 13 (depends on 1) A composition according to claim 1, which exhibits a reduction of at least 3.5 log 10 against poliovirus type 1 (Sabin) (“PV1”) according to ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension. ### Claim 14 (depends on 13) A composition according to claim 13, which exhibits a reduction of at least 4.0 log 10 against poliovirus type 1 (Sabin) (“PV I”) according to ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension. ### Claim 15 (depends on 14) A composition according to claim 14, which exhibits a reduction of at least 4.5 log 10 against poliovirus type 1 (Sabin) (“PV1”) according to ASTM E1052 Standard Test Method for Efficacy of Antimicrobial Agents against Viruses in Suspension. ### Claim 16 (depends on 1) A composition according to claim 1, wherein the zinc source material is present in an amount of about 0.001% wt. to about 1% wt. ### Claim 17 (depends on 4) A composition according to claim 4, wherein the zinc source material is present in an amount of about 0.001% wt. to about 1% wt. ### Claim 18 (depends on 7) A composition according to claim 7, wherein the zinc source material is present in an amount of about 0.001% wt. to about 1% wt. ### Claim 19 (depends on 8) A composition according to claim 8, wherein the zinc source material is present in an amount of about 0.001% wt. to about 1% wt.