Carbocyclic sulfone RORγ modulators

The compound having the following formula (I):

• or a stereoisomer or pharmaceutically-acceptable salt thereof, wherein:
• A is a 3-, 4- or 5-membered cycloalkyl or cycloalkenyl ring;
• B is a, —(CH2)r-3-14 membered carbocycle, or —(CH2)r-5-12 membered heterocycle comprising carbon atoms, and 1-4 heteroatoms selected from N, O, and S(O)p;
• R1 and R1′ are, independently at each occurrence, hydrogen, halo, CF3, OCF3, CN, NO2, —(CH2)rOR1b, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 R1a, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra;
• R1a is, independently at each occurrence, hydrogen, ═O, halo, OCF3, CN, NO2, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra;
• R1b is, independently at each occurrence, hydrogen, CF3, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)R1d, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)R1c, —(CH2)rNRbC(O)ORc, —(CH2)rNRbC(O)NR11R11, —(CH2)rS(O)2NR11R11, —(CH2)rNRbS(O)2Rc, C1-6 alkyl substituted with 0-2 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-2 Ra;
• R2 is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-3 R2a, ═CR2aR2a, C2-6 alkenyl substituted with 0-3 R2a, —(CH2)rOR2b, —(CH2)rC(O)R2b, —(CH2)rC(O)OR2b, —(CH2)rOC(O)OR2b, —(CH2)rOC(O)NR11R11, —(CH2)rNR2bC(O)NR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNR2bC(O)R2c, —(CH2)rNR2bC(O)OR2, —(CH2)rNR11R11, —NR2bS(O)pRc, —(CH2)rNR2bS(O)pNR11R11, —(CH2)r-3-10 membered carbocycle substituted with 0-3 R2a or —(CH2)r-4-10 membered heterocycle comprising carbon atoms, and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 R2a;
• or one R2 together with an R2 on an adjacent carbon combine to form a fused ring substituted with 0-3 R2a, wherein the fused ring is selected from 3-10 membered carbocycle substituted with 0-3 R2a, or 3-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 R2a;
• R2a is, independently at each occurrence, hydrogen, ═O, halo, OCF3, CN, NO2, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)R, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra;
• R2b is, independently at each occurrence, hydrogen, CF3, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)R1d, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)R1c, —(CH2)rNRbC(O)ORc, —(CH2)rNRbC(O)NR11R11, —(CH2)rS(O)2NR11R11, —(CH2)rNRbS(O)2Rc, C1-6 alkyl substituted with 0-2 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-2 Ra;
• R2c is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, C3-10 cycloalkyl substituted with 0-3 Ra, C6-10 aryl substituted with 0-3 Ra, or —(CH2)r 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, substituted with 0-3 Ra;
• R2d is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-2 Rd, C1-6 haloalkyl, C(O)NR11R11, C3-6 cycloalkyl substituted with 0-2 Rd, or (CH2)r-phenyl substituted with 0-2 Ra, a 5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, substituted with 0-3 Ra;
• R3 is selected from hydrogen, halo, N3, CN, —(CH2)rOR3b, —(CH2)rNR11R11, C1-6 alkyl substituted with 0-3 R3a, and C3-10 cycloalkyl substituted with 0-3 R3a;
• 4-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, substituted with 0-3 Ra, or together with the carbon atoms to which they are attached, one R3 combines with a second R3 located on an adjacent atom to form a 5-7 membered carbocycle or a 5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatom selected from N, O and S(O)p, each optionally substituted with 0-3 R3a;
• R3a is, independently at each occurrence, hydrogen, ═O, halo, OCF3, OCHF2, CF3, CHF2, CN, NO2, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R11, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 Ra, C2-6 alkenyl substituted with 0-3 Ra, C2-6 alkynyl substituted with 0-3 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or a —(CH2)r-5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra;
• R3b is, independently at each occurrence, hydrogen, CF3, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)R1d, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)R1c, —(CH2)rNRbC(O)ORc, —(CH2)rNRbC(O)NR11R11, —(CH2)rS(O)2NR11R11, —(CH2)rNRbS(O)2Rc, C1-6 alkyl substituted with 0-3 Ra, C1-6 haloalkyl, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Ra, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Ra;
• R11 is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-3 Rd, CF3, C3-10 cycloalkyl substituted with 0-3 Rd, (CH)r-phenyl substituted with 0-3 Rd, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rd;
• or, together with the nitrogen atom to which they are attached, one R1 combines with a second R11 to form a 4-12 membered[DJ1] heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rd;
• Ra is, independently at each occurrence, hydrogen, ═O, halo, OCF3, CF3, CHF2, CN, NO2, —(CH2)rORb, —(CH2)rS(O)pRb, —(CH2)rC(O)Rb, —(CH2)rC(O)ORb, —(CH2)rOC(O)Rb, —(CH2)rNR11R11, —(CH2)rC(O)NR11R11, —(CH2)rNRbC(O)Rc, —(CH2)rNRbC(O)ORc, —NRbC(O)NR11R, —S(O)pNR11R11, —NRbS(O)pRc, C1-6 alkyl substituted with 0-3 Rf, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Rf, C2-6 alkynyl substituted with 0-3 Rf, —(CH2)r-3-14 membered carbocycle substituted with 0-3 Rf, or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf;
• Rb is, independently at each occurrence, hydrogen, C1-6 alkyl substituted with 0-3 Rd, C1-6 haloalkyl, C2-6 alkenyl substituted with 0-3 Rd, C3-6 cycloalkyl substituted with 0-3 Rd, —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf, or (CH2)r-6-10 atom carbocycle substituted with 0-3 Rd;
• Rc is, independently at each occurrence, C1-6 alkyl substituted with 0-3 Rf, (CH2)r—C3-6 cycloalkyl substituted with 0-3 Rf, —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf, or (CH2)r-phenyl substituted with 0-3 Rf;
• Rd is, independently at each occurrence, hydrogen, ═O, halo, OCF3, CF3, CN, NO2, —ORe, —(CH2)rC(O)Rc, —NReRe, —NReC(O)ORc, C(O)NReRe, —NReC(O)Rc, CO2R, —NReSO2Rc, SO2Rc, C1-6 alkyl substituted with 0-3 Rf, C3-6 cycloalkyl substituted with 0-3 Rf, (CH2)r-phenyl substituted with 0-3 Rf or —(CH2)r-5-7 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p substituted with 0-3 Rf;
• Re is, independently at each occurrence, selected from hydrogen, C(O)NRfRf, C1-6 alkyl, C3-6 cycloalkyl, or (CH2)r-phenyl substituted with 0-3 Rf;
• Rf is, independently at each occurrence, hydrogen, ═O, halo, CN, NH2, NH(C1-6 alkyl), N(C1-6 alkyl)2, SO2(C1-6 alkyl), CO2H, CO2(C1-6 alkyl), OH, C3-6 cycloalkyl, CF3 or O(C1-6 alkyl);
• or Rf is, independently at each occurrence, an optionally substituted —(CH2)r-5-10 membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O), phenyl or C3-6 cycloalkyl, each group optionally substituted with 1-3 groups selected from halo, CN, CF3, C1-6 alkyl and O(C1-6 alkyl);
• q and n are independently selected from 0, 1, 2 and 3;
• p is 0, 1, or 2;
• and
• r is 0, 1, 2, 3, or 4.