Chimeric antigen receptors targeting B-cell maturation antigen
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorJames Noble Kochenderfer
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Abstract
The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
Claims19
A chimeric antigen receptor (CAR) comprising an antigen recognition moiety and a T-cell activation moiety, wherein the T-cell activation moiety comprises a transmembrane domain, wherein the antigen recognition moiety is directed against B-cell Maturation Antigen (BCMA).
Dependencies are inferred from the claim text.