Theragnostic particles
AssigneeUniversity of Washington through its Center for Commercialization
InventorsCarlos Enrique Catalano, Jenny Ren-Jye Chang
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Abstract
The present invention provides viral-based nanoparticles for therapeutic and diagnostic use, and methods for making and using the nanoparticles. Specifically, such nanoparticles comprise decoration-competent viral particles shells such as expanded capsids of phages, stabilized with engineered decoration proteins that have been linked to one or more compounds not naturally occurring on a wild type viral capsid.
Claims17
A theragnostic particle, comprising a plurality of engineered decoration proteins bound to an outer surface of decoration competent viral particle shell, wherein the engineered decoration proteins comprise gpDS42C (SEQ ID NO:
- 10)linked to one or more compounds not naturally occurring on a wild type viral capsid, and wherein the one or more compounds have at least one feature selected from the group consisting of:
- (a) the one or more compounds are non-proteinaceous compounds;
- (b) the one or more compounds are present on the theragnostic particle in a defined ratio relative to the engineered decoration protein;
- (c) the one or more compounds comprise two or more different compounds, wherein the two or more different compounds are present on the theragnostic particle in a defined ratio relative to each other;
- and
- (d) the one or more compounds are linked to the engineered decoration protein at a site on the engineered decoration protein other than the N-terminus or the C-terminus, wherein the decoration competent viral particle shell comprises a bacteriophage lambda viral particle shell.
An isolated recombinant protein comprising the amino acid sequence of SEQ ID NO:
- 10 (gpD(S42C)).
Dependencies are inferred from the claim text.