SHIP1 modulators and methods related thereto

A compound of formula (III):

• wherein:
• is an optionally substituted fused oxazolyl, pyrazolyl or thiazolyl;
• R2 is —R8—OR9, —R8—N(R9)2, —R8—O—R10—OR9, —R8—O—R10—N(R9)2, —R8—N(R9)—R10—OR9, —R8—N(R9)—R10—N(R9)2, —R8—OC(O)R9, —R8—C(O)OR9, —R8—C(O)N(R9)2, —N(R9)C(O)OR9, —R8—N(R9)S(O)tR9 (where t is 1 or 2), —R8—N(R9)C(═NR9)N(R9)2, alkyl, alkenyl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted heteroarylalkenyl;
• R4a and R4b are each independently hydrogen, alkyl, alkenyl or alkynyl;
• or R4a is hydrogen, alkyl, alkenyl or alkynyl and R4b is a direct bond to the carbon to which R7 is attached;
• or R4a and R4b together form alkylidene;
• R5 is alkyl or R5 is a direct bond to the carbon at C14;
• R7 is hydrogen, —R8—OR9, —R8—N(R9)2, or a direct bond to C15, provided that when R7 is a direct bond to C15, R4b is not a direct bond to the carbon to which R7 is attached;
• R13 is —R8—OR9, —R8—N(R9)2, —R8—O—R10—OR9, —R8—O—R10—N(R9)2, —R8—N(R9)—R10—OR9, —R8—N(R9)—R10—N(R9)2, —R8—OC(O)R9, —R8—C(O)OR9, —R8—C(O)N(R9)2, —N(R9)C(O)OR9, —R8—N(R9)S(O)tR9 (where t is 1 or 2), —R8—N(R9)C(═NR9)N(R9)2, alkyl, alkenyl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted heterocyclylalkyl, optionally substituted heteroarylalkyl or optionally substituted heteroarylalkenyl;
• each R8 is independently a direct bond, a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain;
• each R9 is hydrogen, alkyl, optionally substituted aryl and optionally substituted aralkyl;
• and
• each R10 is independently a straight or branched alkylene chain, a straight or branched alkenylene chain or a straight or branched alkynylene chain;
• or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof.