Back to results
US 9,765,017 B2Granted
Allosteric hemoglobin modifiers with nitric oxide releasing moiety
AssigneeVirginia Commonwealth University
InventorsMartin K. Safo, Richmond Danso-Danquah, Mohini Ghatge, Jurgen Venitz, Martin Mangino, Kevin R. Ward
Life of this patent
Estimating the term…
Abstract
Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.
Claims9
A compound having the general formula:
- wherein
- R1 and R2 are the same or different and are CH3, Cl, H, OCH3, or 5-carbon cyclic incorporating both R1 and R2;
- R3 is H, OH, COOH, or OC2H5;
- R4 and R5 are the same or different and are H, CH3, cyclic incorporating both R4 and R5 and containing CH3 substituents, OCH3, C2H5, phenyl, or unsubstituted phenyl;
- and
- R6 is a NO containing moiety selected from the group consisting of:
3 more elements
Dependencies are inferred from the claim text.