Suppression of cancer metastasis
AssigneeAcademia Sinica
InventorsShu-Mei Liang, Ching-Feng Chiu, Shao-Wen Hung, Jei-Ming Peng, Chi-Ming Liang
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Abstract
Methods of using fibrillar proteins are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment in vitro. In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis.
Claims10
A method for suppressing human cancer metastasis comprising:
- administering to a human having a metastatic cancer an effective amount of fibrillar human serum albumin and a pharmaceutically acceptable carrier, wherein said administering reduces cancer metastasis in said human, and wherein said fibrillar human serum albumin is produced by a method comprising:
- dissolving human serum albumin in a detergent solution to provide dissolved human serum albumin;
- applying said dissolved human serum albumin through a gel filtration column with a pore size that can separate proteins of 70 kDa molecular weight and above;
- eluting said dissolved human serum albumin from said gel filtration column to provide an eluate;
- and
- removing said detergent from said eluate.
Dependencies are inferred from the claim text.