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US 9,758,500 B2Granted
Process for the preparation of (3E, 7E)-homofarnesol
AssigneeBASF SE
InventorsMelanie Weingarten, Hansgeorg Ernst, Wolfgang Siegel, Ekkehard Winterfeldt, Reinhard W. Hoffmann
Life of this patent
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Abstract
The present invention relates to new types of processes for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol preparations with an increased content of (3E,7E)-homofarnesol (also referred to as all E-homofarnesol).
Claims15
A process for preparing compounds of formula I
- in which
- R1 is a straight-chain or branched, optionally mono- or polyunsaturated hydrocarbyl radical, and R2 is H or C1-C6-alkyl, where
- a) a carbonyl compound of formula II
- in which R1 and R2 have the meanings above, is reacted by means of Wittig olefination to give a cyclopropane of formula (III)
- b) the cyclopropane of the formula III is reacted, with ring opening, to give a compound of formula IV
- in which X is halogen or O—R′, in which R′ is H, acyl, Tf-acetyl or SO2—R″, and R″ is alkyl or aryl;
- and
- c) the compound of the formula IV is converted to the formula I compound.
5 more elements
Dependencies are inferred from the claim text.