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US 9,758,459 B2Granted
Allosteric modulators of factor XIa as anticoagulant agents
AssigneeVirginia Commonwealth University
InventorsUmesh R. Desai, Rajesh Karuturi, Akul Mehta, Rami A. Al-Horani
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Abstract
Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated gallolyl glucosides, ii) sulfated quinazolinones, and iii) sulfated inositol analogs. The compounds used as anticoagulant agents.
Claims4
A compound of Formula XI
- wherein each R is independently selected from
- i)
- where each X is independently selected from —H, —OH, —OCH3, —OSO3−, —OPO3−2, and —COO−
- and
- ii) Y, where each Y is independently selected from, —OH, —OSO3−, —OPO3−2 and —COO−;
- with the caveats that at least one R is
- and at least one X or one Y is —OSO3−;
- and stereoisomers and pharmaceutically acceptable salts thereof.
5 more elements
Dependencies are inferred from the claim text.