Iron oxide nanocapsules, method of manufacturing the same, and MRI contrast agent using the same
AssigneeHanwha Chemical Corporation
InventorsBong-Sik Jeon, Eung Gyu Kim, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
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Abstract
Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. 5≦100*Dμ(IO)/Cω(IO) [Relation 1] 2.5≦100*Dμ(Cap)/Cω(Cap) [Relation 2] 0.5 wt %≦F(IO)≦50 wt % [Relation 3] 1 nm≦Dμ(IO)≦25 nm [Relation 4] 50 nm≦Dμ(Cap)≦200 nm [Relation 5]
Claims9
Iron oxide nanocapsules, in which a plurality of iron oxide nanoparticles having an oleate ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below:
- 10≦100*Dm(IO)/Cv(IO) Relation 1
- 2.5≦100*Dm(Cap)/Cv(Cap) Relation 2
- 7 wt %≦F(IO)≦35 wt % Relation 3
- 1 nm≦Dm(IO)≦25 nm Relation 4
- 50 nm≦Dm(Cap)≦200 nm Relation 5
- in which:
- in Relation 1, Dm(IO) is an average size of iron oxide nanoparticles, and Cv(IO) is a standard deviation in size distribution of iron oxide nanoparticles, and
- in Relation 2, Dm(Cap) is an average size of iron oxide nanocapsules, and Cv(Cap) is a standard deviation in size distribution of iron oxide nanocapsules, and
- in Relation 3, F(IO) is encapsulation efficiency which refers wt % of iron oxide nanoparticles encapsulated in the iron oxide nanocapsules, and
- in Relation 4, Dm(IO) is defined as in Relation 1, and
- in Relation 5, Dm(Cap) is defined as in Relation 2.
Dependencies are inferred from the claim text.