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US 9,757,394 B2Granted
Spironolactone aqueous formulations
AssigneeCmp Development LLC
InventorsAnthony Pipho, Michael Paul DeHart
Life of this patent
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Abstract
Disclosed herein is a pharmaceutical composition, comprising: (a) spironolactone; (b) a xanthan gum; (c) an anti-foaming agent; (d) a preservative; (f) a dispersing agent; (g) a sweetening agent; (h) a flavoring agent; (i) optionally a buffer to maintain the pH of the pharmaceutical composition within a range described herein; and (j) a sufficient amount of a water vehicle.
Claims27
A pharmaceutical composition, comprising:
- (a) 0.50% w/v of spironolactone;
- (b) from 0.18% w/v to 0.36% w/v of a xanthan gum;
- (c) an anti-foaming agent comprised of 0.20% w/v of a simethicone emulsion;
- (d) a preservative comprised of from 0.025% w/v to 0.050% w/v of sorbic acid and from 0.10% w/v to 0.20% w/v of potassium sorbate;
- (e) a dispersing agent comprised of from 2.0% w/v to 2.2% w/v glycerin;
- (f) a sweetening agent comprises 0.14% w/v sodium saccharin and from 0.03% w/v to 0.04% w/v ammonium glycyrrhizinate;
- (g) a flavoring agent in an amount that ranges from 0.1% w/v to 0.5% w/v;
- (h) a buffer to maintain the pH of the pharmaceutical composition from 4.5 to 5.5;
- wherein the buffer is comprised of from 0.17% w/v to 0.24% w/v citric acid and from 0.36% w/v to 0.48% w/v of a citrate salt;
- and
- (i) a sufficient amount of a water vehicle.
8 more elements
A pharmaceutical composition comprising:
- (a) 0.50% w/v spironolactone;
- (b) 0.25% w/v of a xanthan gum;
- (c) 0.20% w/v of a simethicone emulsion;
- (d) a preservative comprised of 0.050% w/v of sorbic acid and 0.20% w/v of potassium sorbate;
- (e) from 2.1% w/v to 2.2% w/v glycerin;
- (f) a sweetening agent containing 0.14% w/v sodium saccharin and from 0.03% w/v to 0.04% w/v ammonium glycyrrhizinate;
- (g) 0.30% w/v of a fruit flavoring agent;
- (h) a buffer comprised of 0.20% w/v citric acid and 0.43% w/v sodium citrate;
- and (i) a sufficient amount of a water vehicle.
6 more elements
Dependencies are inferred from the claim text.