Method and system for microbiome-derived characterization, diagnostics and therapeutics for cardiovascular disease conditions

A method for characterizing a cardiovascular disease condition in a subject, the method comprising:

• for each of an aggregate set of samples from a population of subjects:
• determining a microorganism nucleic acid sequence, comprising:
• identifying primers for nucleic acid sequences associated with the cardiovascular disease condition,
• fragmenting nucleic acid material from the biological sample, and
• amplifying the fragmented nucleic acid material using the identified primers;
• and
• determining an alignment of the microorganism nucleic acid sequence to a reference nucleic acid sequence associated with the cardiovascular disease condition;
• generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects based on the alignment, the microbiome functional diversity dataset indicative of systemic functions present in the microbiome components of the aggregate set of samples;
• at the computing system, features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset into a characterization model of the cardiovascular disease condition, wherein the characterization model is diagnostic of at least one of coronary heart disease, inflammatory heart disease, and valvular heart disease;
• based upon the characterization model, generating a therapy model configured to improve a state of the cardiovascular disease condition;
• and
• at an output device associated with the subject, providing a therapy to the subject with the cardiovascular disease condition, upon processing a sample from the subject with the characterization model, in accordance with the therapy model, wherein the therapy modulates microbiome composition to improve a state of the cardiovascular disease condition.