# US 9,753,187 B2 · Low hydrous soft ophthalmic lens and method for manufacturing the same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 9,753,187 B2 - Document ID: US9753187B2 - Status: Granted - Kind: B2 - Application number: 14/239,071 - Filed: 2012-08-15 - Published: 2014-11-13 - Granted: 2017-09-05 - Earliest claimed: 2011-08-17 - Assignees: Toray Industries, Inc. - Applicants: Rumiko Kitagawa; Masataka Nakamura; Satoru Ogasahara - Inventors: Rumiko Kitagawa; Masataka Nakamura; Satoru Ogasahara - Web page: https://patentgrep.com/patent/US9753187B2 ## CPC - G02B 1/043: {Contact lenses} - A61F 2/14: Eye parts, e.g. lenses or corneal implants; Artificial eyes - A61F 2/1613: {having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus} - A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds - A61L 27/50: Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} - A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} - B29D 11/00009: {Production of simple or compound lenses} - B29D 11/00038: {Production of contact lenses} - B29D 11/00865: {Applying coatings; tinting; colouring (printing, marking or copying processes B41M; identification in general G09F3/00; producing decorative effects in general B44C; positioning or marking of lenses B24B13/0055)} - C08L 33/02: Homopolymers or copolymers of acids; Metal or ammonium salts thereof - C08L 33/26: Homopolymers or copolymers of acrylamide or methacrylamide - C08L 79/02: Polyamines - G02B 1/12: by surface treatment, e.g. by irradiation - A61L 2430/16: for reconstruction of eye parts, e.g. intraocular lens, cornea - C08L 2205/03: containing three or more polymers in a blend - G02B: OPTICAL ELEMENTS, SYSTEMS OR APPARATUS - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - B29D: PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE (making granules B29B9/00; making preforms B29B11/00) - C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06) ## Abstract Provided are a low hydrous soft ophthalmic lens that can remarkably reduce or avoid a phenomenon in which a lens sticks to a cornea when worn and can reduce a decrease in the performance of a coating layer when rubbing the low hydrous soft ophthalmic lens for cleaning and a method for manufacturing the same. The low hydrous soft ophthalmic lens has a layer formed of a hydrophilic polymer on at least part of the surface of a base material containing a polysiloxane compound, and at least part of the inside of the layer is cross-linked. ## Claims ### Claim 1 A low hydrous soft ophthalmic lens comprising: a base material; and a layer formed of a hydrophilic polymer on at least part of a surface of the base material, at least part of inside of the layer being cross-linked, wherein the low hydrous soft ophthalmic lens has a water content of less than 1% by mass. ### Claim 2 (depends on 1) The low hydrous soft ophthalmic lens according to claim 1, wherein the hydrophilic polymer is an acidic polymer and/or basic polymer. ### Claim 3 (depends on 1) The low hydrous soft ophthalmic lens according to claim 1, wherein the base material and the layer cross-link therebetween at least partially. ### Claim 4 (depends on 1) The low hydrous soft ophthalmic lens according to claim 1, wherein part of the inside of the layer is cross-linked by irradiating the base material with radiation while the hydrophilic polymer is attached to the base material. ### Claim 5 (depends on 1) The low hydrous soft ophthalmic lens according to claim 1, wherein the base material has, as a main component, a polymer of a component A below or a copolymer of the component A below and a component B below: the component A is a polysiloxane compound having a plurality of polymerizable functional groups per molecule and a number average molecular weight of 6,000 or more; and the component B is a polymerizable monomer having a fluoroalkyl group. ### Claim 6 (depends on 1) The low hydrous soft ophthalmic lens according to claim 1, wherein the layer is formed by performing treatment with an acidic polymer solution once or twice and treatment with a basic polymer solution once or twice, these pieces of treatment being performed three times in total. ### Claim 7 (depends on 6) The low hydrous soft ophthalmic lens according to claim 6, wherein the layer is formed by performing treatment with two kinds of acidic polymer solutions twice and treatment with a basic polymer solution once. ### Claim 8 (depends on 1) The low hydrous soft ophthalmic lens according to claim 1, wherein at least one kind of hydrophilic polymer forming the layer is a polymer having a group selected from a hydroxy group and an amido group.