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US 9,753,041 B2Granted
Salivary inflammatory biomarkers associated with glycemic control and oral health
AssigneeUniveristy of South Florida
InventorsAmy Christine Alman, Brant Roger Burkhardt
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Abstract
The present invention provides non-invasive diagnostic methods and kits for determining and/or monitoring oral health and glycemic control in subjects with Type 1 diabetes.
Claims3
A method for determining the levels of a set of biomarkers consisting of TNF-α, IL-1β, MMP-8, and MMP-9 in a saliva sample of a subject having Type I diabetes, the method comprising the steps of:
- a) obtaining the saliva sample from the subject,
- b) contacting the saliva sample with binding partners that specifically bind to TNF-α, IL-1β, MMP-8, and MMP-9 to form complexes between the binding partners and TNF-α, IL-1β, MMP-8, and MMP-9,
- c) detecting the formation of the complexes using a system generating quantifiable signals, and
- d) determining the levels of each biomarker from the set of biomarkers based on the quantifiable signals.
1 more element
Dependencies are inferred from the claim text.