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US 9,751,957 B2Granted
Manufacturing process for cyclodextrin derivatives
AssigneeCyDex Pharmaceuticals, Inc.
InventorsVincent D. Antle, Jose R. Matos
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Abstract
A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.
Claims28
A process for preparing a derivatized cyclodextrin, the process comprising:
- reacting a cyclodextrin starting material, a substituent precursor, and an optional catalyst to provide a raw product comprising a derivatized cyclodextrin, wherein:
- the raw product comprises 1% or less of an initial amount of the substituent precursor, and
- the reacting is performed in a continuous or semi-continuous manner comprising:
- providing a feedstock comprising a liquid or gas medium, the cyclodextrin starting material, the substituent precursor, and the optional catalyst;
- and
- continuously or semi-continuously flowing the feedstock into a flow-through reactor and simultaneously flowing out of the flow-through reactor the raw product comprising a derivatized cyclodextrin;
- wherein the feedstock has a residence time in the flow-through reactor of 0.5 sec to 30 minutes, and the flow-through reactor temperature is 70° C. to 200° C.
4 more elements
A process for preparing a derivatized cyclodextrin, the process comprising:
- combining in a liquid or gas medium a cyclodextrin starting material, a sulfoalkylating agent present in a molar excess relative to the cyclodextrin starting material, and an alkalinizing agent present in a molar excess relative to the one or more sulfoalkylating agents to form a feedstock;
- and
- reacting the feedstock by continuously or semi-continuously flowing the feedstock into and out of a flow-through reactor for a residence time of 0.5 sec to 30 minutes, at a temperature of 70° C. to 200° C., and at a pressure of 1 bar or higher to form a raw product comprising the derivatized cyclodextrin and 1% or less of an initial amount of the substituent precursor.
Dependencies are inferred from the claim text.