# US 9,751,952 B2 · Human-derived insect-resistant gene and anti-Cry1B toxin idiotype single-chain antibody encoded thereby and application thereof

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- Number: US 9,751,952 B2
- Document ID: US9751952B2
- Status: Granted
- Kind: B2
- Application number: 15/104,150
- Filed: 2015-01-09
- Published: 2017-02-16
- Granted: 2017-09-05
- Earliest claimed: 2014-01-26
- Assignees: Jiangsu Academy of Agricultural Sciences Institute of Food Safety and Monitoring Technology
- Applicants: Jiangsu Academy of Agricultural Sciences
- Inventors: Xianjin Liu; Chongxin Xu; Xiao Zhang; Yuan Liu; Yajing Xie; Cunzheng Zhang; Xiangyang Yu; Donglan Wang
- Web page: https://patentgrep.com/patent/US9751952B2

## CPC

- C07K 16/4233: {against anti-bacterial Ig}
- A01N 63/50: Isolated enzymes; Isolated proteins (peptides A01N37/46)
- C07K 16/42: against immunoglobulins
- C07K 2317/14: Specific host cells or culture conditions, e.g. components, pH or temperature
- C07K 2317/24: containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C07K 2317/622: Single chain antibody (scFv)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS

## Abstract

An anthropogenic pest-resistant gene having a nucleotide sequence as represented by SEQ IN NO. 1, and, an anti-Cry1Ab toxin idiotypic single-chain antibody encoded by the anthropogenic pest-resistant gene and having a nucleotide sequence as represented by SEQ IN NO. 2.

## Claims

### Claim 1

A single-chain antibody comprising the amino acid sequence represented by SEQ ID NO.2.

### Claim 2 (depends on 1)

An insecticide comprising the single-chain antibody of claim 1.