Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof

A compound comprising:

• a solomonamide analogue of Formula I
• wherein the Ring A is selected from the group consisting of a substituted or an unsubstituted aryl, a substituted or an unsubstituted heteroaryl, a substituted or an unsubstituted cycloalkyl, a substituted or an unsubstituted bicyclic compound, or a substituted or an unsubstituted heterocyclic compound;
• wherein the dipeptide is selected from the group consisting of two natural amino acids or two unnatural amino acids;
• wherein X is selected from the group consisting of O, NRa, S, —S(O), S(O)2, C(O), C(O)O, C(O)NRa, CRaRb;
• wherein the bond between X and an adjacent carbon atom is optionally a double bond;
• and wherein the bond between X and the adjacent carbon atom is optionally part of a 3 to 6-membered cycle having 1 or 2 hetero atoms;
• wherein R1 and R2 is independently selected from the group consisting of H, OH, OR, NRa, alkyl, aralkyl, substituted heteroatoms, unsubstituted heteroatoms, and amino acids;
• and wherein R1 and R2 substituents are attached to carbon atom optionally expresses chirality;
• wherein n is 0, 1, 2, or 3;
• wherein the ‘R’ substituent is selected from the group consisting of alkyl, aralkyl, C(O)ORa, or C(O)NRaRa;
• ‘Ra’ is selected from the group consisting of H, OH, alkyl, and aralkyl;
• and
• ‘Rb’ is selected from the group consisting of H, OH, alkyl, aralkyl, OR, and NRaRa
• with a proviso that when the dipeptide is Gly-D-Ala, Ring A is the substituted aryl, X is C(O) and n is 1, then the solomonamide analogues chosen from