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US 9,751,857 B2Granted
Hepatitis B antiviral agents
AssigneeNovira Therapeutics, Inc.
InventorsGeorge D. Hartman, Osvaldo A. Flores
Life of this patent
Estimating the term…
Abstract
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
Claims15
A compound of Formula (III):
- or a pharmaceutically acceptable salt thereof;
- wherein:
- the substituents —C(═O)N(R6)2 and —C(═O)NR4— are in a 1,3-position with respect to each other;
- ring B is a monocyclic aryl ring;
- R2 and R5 are independently selected at each occurrence from the group consisting of halo, —CN, —NO2, -(L)m-OR8, -(L)m-C(═O)R9, -(L)m-OC(═O)R9, -(L)mCO2R8, -(L)m-CH(R8)2, -(L)m-N(R8)2, -(L)m-C(OH)(R8)2, -(L)mC(NH2)(R8)2, —C1-C6 alkyl, and —C1-C6 heteroalkyl;
- R4 is H;
- the R6 groups attached to the same N atom are taken together with the N atom to which they are attached to form an optionally substituted C2-C10 heterocycloalkyl ring, wherein the ring optionally comprises a moiety selected from N—R4, and wherein the heterocycloalkyl ring is optionally substituted with 0-5 substituents selected from R2;
- each RB is independently, at each occurrence, H or C1-C6 alkyl;
- R9 is C1-C6 alkyl or C3-C10 cycloalkyl;
- each occurrence of y is independently selected from the group consisting of 0, 1, 2, 3 and 4;
- each occurrence of x is 0;
- L is independently, at each occurrence, a bivalent radical selected from —(C1-C3 alkylene)m-, and —(C1-C3 alkylene)m-O—(C1-C3 alkylene)m-;
- and
- each occurrence of m is independently 0, 1 or 2.
11 more elements
Dependencies are inferred from the claim text.